ID   A0A3B4CXX7_PYGNA        Unreviewed;      1025 AA.
AC   A0A3B4CXX7;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=F-BAR domain only protein 2 {ECO:0000256|ARBA:ARBA00018998};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000015389.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000015389.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004283}.
CC   -!- SIMILARITY: Belongs to the FCHO family.
CC       {ECO:0000256|ARBA:ARBA00011064}.
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DR   RefSeq; XP_017554024.1; XM_017698535.1.
DR   AlphaFoldDB; A0A3B4CXX7; -.
DR   STRING; 42514.ENSPNAP00000015389; -.
DR   Ensembl; ENSPNAT00000023573.1; ENSPNAP00000015389.1; ENSPNAG00000021417.1.
DR   GeneID; 108427942; -.
DR   CTD; 115548; -.
DR   GeneTree; ENSGT00940000157105; -.
DR   OrthoDB; 2996449at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   CDD; cd07673; F-BAR_FCHO2; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR030122; FCHo2_F-BAR.
DR   InterPro; IPR028565; MHD.
DR   InterPro; IPR018808; Muniscin_C.
DR   PANTHER; PTHR23065:SF8; F-BAR DOMAIN ONLY PROTEIN 2; 1.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF10291; muHD; 1.
DR   SMART; SM00055; FCH; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT   DOMAIN          4..250
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          757..1025
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
FT   REGION          280..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..720
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          87..156
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        281..306
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..437
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..523
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..617
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        636..665
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        696..720
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1025 AA;  111908 MW;  1267A0A4668586CE CRC64;
     MITPYFLENF WGEKNNGFDV LYHNMKHGQI SSKELSDFIR ERATIEETYS RSMTKLAKSA
     SNFSQLGTFA PVWDVFKVST EKLAACHMEL VRKLQELIKE VQKYVDEQAK AHKKTKEEVA
     STLEAVQNIQ SVSQALQKSK ENYNSKTLEL ERMRKEGATQ RDLDKAGVKV KKATEVYKSY
     VEKYASTKTE FEQKMAETAQ KFQDIEESHI QHMKEIIQSY SCSVEDTHKQ IIEVHKEFVN
     NMENTSAAGL IQKLAESKGT GKERPGPIEF EECNVSIATE GAKPRKRKPF TIPGRRKDKD
     TDSTESTEVE ATNTANGAPP DFYGAIDIQN ANVPQVDEEG FCIRPEVNEN DAKDNSFYSS
     SDSEEEDERR KFHVEIKPVQ PNNGTHQHKA TIDELKASIG NITLSPSATV HMRRNQSSDE
     LGRSRTQQPS YNDRLANNDL LSLDPFGPSA GGSTSSGSSS AAPPAVGVVF QQEPSSPPAD
     QPEAKEAFAG SVPPKLTSPL PPPSSSPPPF PALPSPPSTS PWDIPDEPFT SLLPALPRAT
     SVPPTLPANL GDIISHKPPL SAPATGTDTL SSWTQSQWVA FNDDFVPFRG PSRLPPRPQS
     VPAPQLLSSQ ATDAFTKEES APCQMEDHRA PPSAGHSQDV PPPNRPSTPL GTGTIVPPPR
     PSSRPKLPAG KLTGINEIGR PFSPPKVANS SPPPTAPLAR AESSSSLSSN TSLSASNTPT
     VEDDVFVGKL PTFEKRCETP AGTSRGPSPV TLASQDPLPI AVAFTESVNA YFKGADPSKC
     IVKITGDMTL SFPSGIIKIF TSSPSPAVLS FKLRNTSKLE QILPNQHLLH SDSSQSDTNT
     KDFWLNMPAL TAYLRKCSEQ NPVSSYYNVD VLKYQVCSNG IQSTPLNLAV YWKCGSSTTD
     LRIDYRYNPE AMQPPGPLTS VQVLVPVNGG VTNMQSLPNA IWNTEQSKSL WKLNDISEKS
     ENEGSGSLRA KFELSDGPSI PATLAVQFFN EGSTLSGVDM ELVGSGYRLS LNKKRFTSGR
     YMADC
//