ID A0A3B4CZL0_PYGNA Unreviewed; 190 AA.
AC A0A3B4CZL0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Endothelin-2-like {ECO:0000313|Ensembl:ENSPNAP00000016236.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000016236.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000016236.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000256|ARBA:ARBA00010959}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017579567.1; XM_017724078.1.
DR AlphaFoldDB; A0A3B4CZL0; -.
DR STRING; 42514.ENSPNAP00000016236; -.
DR Ensembl; ENSPNAT00000038048.1; ENSPNAP00000016236.1; ENSPNAG00000022363.1.
DR GeneID; 108443424; -.
DR GeneTree; ENSGT00950000183053; -.
DR OMA; SPIARWR; -.
DR OrthoDB; 4317037at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR PANTHER; PTHR13874; ENDOTHELIN; 1.
DR PANTHER; PTHR13874:SF9; ENDOTHELIN-2; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 2.
PE 3: Inferred from homology;
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasoconstrictor {ECO:0000256|ARBA:ARBA00023322}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..190
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017240096"
FT DOMAIN 44..65
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
FT DOMAIN 90..111
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
SQ SEQUENCE 190 AA; 21232 MW; 8AA6087E47626E17 CRC64;
MALYTILLFS ISWSAALHEG LGLPVIGQSD VSGPEHARRV RTKRCSCNNQ LDSECHYFCH
MDIVWVTTPS KTTVYGLGSP IARWRRSTDR CLCANPADQT CNSFCVHRSK NVAAMLKTQS
KPVQENSDLQ PVLENLDNAE PVVIIEGTED KARANVLTFL RSLMKAKFQA MERNVRHSER
GAKAHKPGYS
//
