ID   A0A3B4CZN1_PYGNA        Unreviewed;       941 AA.
AC   A0A3B4CZN1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Solute carrier family 12 member 9-like {ECO:0000313|Ensembl:ENSPNAP00000016778.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000016778.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000016778.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   RefSeq; XP_017541370.1; XM_017685881.1.
DR   AlphaFoldDB; A0A3B4CZN1; -.
DR   STRING; 42514.ENSPNAP00000016778; -.
DR   Ensembl; ENSPNAT00000038261.1; ENSPNAP00000016778.1; ENSPNAG00000022983.1.
DR   GeneID; 108413394; -.
DR   GeneTree; ENSGT00940000164152; -.
DR   OMA; NDLPCRA; -.
DR   OrthoDB; 5490251at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF96; SOLUTE CARRIER FAMILY 12 MEMBER 9; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        50..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        85..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        317..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        406..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        429..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        463..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        488..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          55..547
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          559..646
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   DOMAIN          768..933
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
FT   REGION          19..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  104807 MW;  5F736F802E2D5F58 CRC64;
     MTERTPLLHY RLSASINESG EHHSESGQEA LDQPPSAVRR RSAHSQPQKL STFFGVVIPT
     LLSMFSVVVF LRIGFVVGQC GLYQAVAMFL VAYLIISMTV LSVCAISTNG ALDAGGAYYM
     ISRALGPEFG GSIGIMFFFA NVCGSALYVL GLVEAILATF GISEDGMDSS SRYAVLPVSY
     WWSLLYATAI LLVCLLVCLV GAWIYAKASF LIFLVVMVVL GTIFISFFAV KPQTVTLPGH
     LTNSSPTTAN FTGFKAETFF QNLGADYTVD YTTGKMMSFA TVFAVMFNGC TGIMAGSNIS
     GDLKNPSYAI PRGTITAVIF TFIIYNLLSL LVACTCDRLL LQRDYSFLRD INLWHPFVTI
     GVYSSTLSAA MSNLIGASRI LYALARDDLF GKVLSPAKKT SASGNPWVSV LISWFLVQLV
     LFSGKLNTIA SIVTIFFLLV YAAVDLACLA LEWASAPNFR PTFRYFTWHT CVLGIVGCGV
     MMFLINPIYA SASIVFMLLL LLIIHYLSPT SSWGYISQAL IFHQVRKYLL MLDVRKDHVK
     FWRPQVLLMV ANPRANIGLI TFINDIKKSG LYVLGHVQIG DLGLLPSDPL QCQYDSWLSL
     VDHLNIKAFV NLTLADSVRH GVRHLLFISG LGGMRPNTLV LGFYDDLPPQ DQLQDHSFHS
     DRSLDDPALA EDQEDPLFHF PPLRGSVPED KNRGEAWVGK ALGPQEYVSI IADAVKMLKN
     VALARYFGQF DRKHALQSPV FVDVWPVNLL RPDSSSYVDT CSLFLLQLAC ILNMTRSWQK
     AKLRLFLCVE VGRSLKGAEQ KLRLLLKELR MKADIYMVPW DEQVALHWQR QHVGMAIEAE
     PEKGERDEVQ KEDEEEVEEE EYANSFPSNA VRLSDDYLHA VNRLILNQPR PPPAVRFLYL
     PRPPADTRRY HNYLCQLELL SRDLGPTLLI HGVTPVITTD L
//