ID   A0A3B4CZS8_PYGNA        Unreviewed;       978 AA.
AC   A0A3B4CZS8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase 3 {ECO:0000313|Ensembl:ENSPNAP00000016818.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000016818.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000016818.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4CZS8; -.
DR   Ensembl; ENSPNAT00000038286.1; ENSPNAP00000016818.1; ENSPNAG00000023138.1.
DR   GeneTree; ENSGT00940000158189; -.
DR   OMA; MYSSEQC; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   PANTHER; PTHR22870:SF463; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR   PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF00415; RCC1; 7.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS00626; RCC1_2; 3.
DR   PROSITE; PS50012; RCC1_3; 7.
PE   4: Predicted;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   REPEAT          1..51
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          52..101
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          102..154
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          155..207
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          208..259
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          260..311
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          313..364
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          651..978
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        946
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   978 AA;  108426 MW;  03D9B0016ACF0851 CRC64;
     MLCWGSSAWG QLGLGNSESA VFEPRSCRML NGKGLKEVAC GGQHSLFLLH DGSVYTCGSN
     SRGQLGHEKT GTKPELVVAL DAQKIASMAC GEAHSLAVNE QGQVFAWGAG DGGQLGLGTA
     EEAVRVPRLI KKLCEHRISQ VMCGNQHCIA LSKDGQLFTW GQNSSGQLGL GKGEPSSLSP
     QPLKSLCGIP LAQISAGGDH SFALSLSGAV FGWGRNSAGQ LGLNDEQDRA VPCHIKFLRS
     QKVVYISCGE EHTAALTKDG GLFTFGNGSR GQLGHDSTNN EPLPRRVLEL MGTEVSQIAC
     GKHHTLAFVP STGLVYAFGC NAHGQLGLGT RGHAKIPMPV RNIQPPYLSS TQTAGYDIIL
     LLSSTACWNA SFLDQSDDGH FKTNPKVPGI DLNSVRLLFE TLMKPAYSRL LEQTTKSFES
     LLIPQLPCSP PDVEAMRIYL ILSECPALHD SKNYISLTIP LAMAILRLDT NPSKVLDNWW
     SLVDCEVFSR LVEMYKSIVV FLLTSGKALL IPVFLESYIS ATLRLLEKLH KVNQKAQHVE
     YNCFYIPDVT SLVDIQEDYL KWFLILMRGF HFQSSVTLCA YPFILNAQAK TTMLQTDAEL
     QMQMAVSGAN LHNVFMLLTL EPLLAQNPFL VLHVRRDHLV SDALRELTIY NDVDLKKPLK
     VIFDGEEAVD AGGVTKEFFL LLLKELMDPV YGMFTHYPES NLLWFSDKCF VEHNWFHLIG
     IVCGLAIYNS TVVDLHFPLV LYKKLLDVCP ALDDLKELSP TEGRSLQQLL DYEGDDVEEA
     FCLNFAITRE HYGVTEVKEL VPGGENITVV RSNREEFVQA YLRYVFSDSV QELYSAFSGG
     FLKVCGGRIL SLFQPSELMA MVVGNSSYNW EELEKNAVYK GEFSASHPTV RMFWEVFHNF
     PLEKKKQFLL FLTGSDRIPI HGMASLRIVL QSTSAAEHYL PVAHTCYNLL DMPCYKTKET
     LHTRLTRAIE QYEGFSLV
//