ID A0A3B4D004_PYGNA Unreviewed; 957 AA.
AC A0A3B4D004;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A5 {ECO:0000313|Ensembl:ENSPNAP00000016893.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000016893.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000016893.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3B4D004; -.
DR Ensembl; ENSPNAT00000038305.1; ENSPNAP00000016893.1; ENSPNAG00000023167.1.
DR GeneTree; ENSGT00940000157488; -.
DR OMA; RETEGNC; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 421..452
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 472..493
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 642..660
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 690..709
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 730..754
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 790..809
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 816..835
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 867..898
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 26..299
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 358..868
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 107..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..950
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 957 AA; 108194 MW; E970AC761CBF066B CRC64;
MDTLQHDGEE LEWRESARWV KFEEKVEEGG ERWSKPHVST LSLHSLFELR TCLQTGVVLL
DLEGYSLPQI VDDIIERQIE EGMIGPELRD KISFVLLRKH RHQTKKPIHR SLADMGKGSS
GAPRSPARSP AAASTFNRST EDLRSKQAGS YGRLRECYNM QVRFINKPPP PHLFFLQLEL
QLKNKFMKKI PRDAEASNVL VGEVDFLDKP FVAFVRLAQA TTLGGLTEVP VPTRFLFVLL
GPHGKAKSYN EIGRAIATLM VDDLFSDVAY KARDREDLIA GIDEFLDEVI VLPPGEWDPK
IRIEPPKKVL SADKRKSVFS LNELGQMNGS VGGGGGVSED EEMPVPHELG EELAYTGRFC
GGLFLDIKRK LPWYPSDFYE GFHIQSISAV LFIYLGCITN AITFGGLLGD ATDNYQGVME
SFLGTALAGT VFCLFGGQPL IILSSTGPIL IFEKLLYEFS KSNSIDYMEL RLWIGMHACA
QCLFLVATDA SYIIKYMTRF TEEGFSSLIS FIFISDAIKK MVGSFKYYPI NTEFNPDYVT
AYKCECVAPD PNEVNDVDYL VTMTHFNLYW MNITALDWTQ LSKKECVKYG GSLVGKSCKY
VPDLALMSFI LFFGTYSMTV SLKKFKFSRY FPTKLRKLIS DFSIFMSIMT FVGLDMLIGL
KTPKLIVPTE FKPTRPDRGW IVMPFGKNPW WVYVASFVPA LLVTILIFMD QQISAVIVNR
KENKLKKGCG YHLDLFWVGL LMAACSFIGL PWYVAATVIS IAHIDSLKME SESSAPGEQP
QFLGVREQRM TGILVFVLTG VSIFLAPVLQ FIPMPVLYGV FLYMGVASLG GIQFWDRTKL
FLMPAKHQPD FTYLRHVPLR RVHLFTLLQI VCLAVLWILK STFLAIIFPV MILGLMLVRK
MLDMVFSQHD LAWLDDLLPE KEKKKKDDEK KNSSSKKDKK KGRVGDDSED DVSLAFE
//
