ID A0A3B4D0H0_PYGNA Unreviewed; 1108 AA.
AC A0A3B4D0H0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cubilin-like {ECO:0000313|Ensembl:ENSPNAP00000017053.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000017053.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000017053.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; A0A3B4D0H0; -.
DR STRING; 42514.ENSPNAP00000017053; -.
DR Ensembl; ENSPNAT00000025707.1; ENSPNAP00000017053.1; ENSPNAG00000023299.1.
DR GeneTree; ENSGT01030000234528; -.
DR OMA; QVWPASQ; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00041; CUB; 6.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 6.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24251:SF37; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 6.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00042; CUB; 6.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 6.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS01180; CUB; 6.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}.
FT DOMAIN 47..155
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 166..279
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 312..423
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 434..549
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 589..836
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 847..957
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 968..1078
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 39..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 120894 MW; 5C814FC84DAD26BA CRC64;
MASKKGLTNL EKSLIVLFVA MTLACIGLIV VYVTERNNSK TENKEGDPGQ LSGNSGEFSS
GNYPSNYNNG MSCSWHITVE NNKVIHLWFQ DFSLEDSGTC SADSLTLRDN LGIIGKYCGH
SKPKPVVSLG NTLVVYFDTN DRQMDRGFKA MYHAVDPEAV TEIVGAGGVL QGDRGELMTP
GFPEQSYESG VLYQWRIVVS AGNKVHLNFT AFDLVPDSCG DFVDVFDGHS DDVSATKLGH
FCGNQMPEPV VSSSNEMVVR FKSDSGQTAK GFSAVYTVVT DPPVTSTTTT TSTTQTNTTT
PSITSAPIDS GCGSLETLSG RKGVIHSLGF PNVYPANLQC SWNISVDEGL LIKLHITDLA
IVGEAGQCGQ DQLTVSDSQQ SLGTHCGFIL PPVLVSVSNR MSLTFQSDGR LADRGFSARW
EAVYPEDIAE IQGCGVFSHE EMGVIKSENW PMNYPPNREC LWKVQVPEGK TITLTFTQFD
MEAAGILLGR CLDNVIIYDG SQPMAKKYGP YCGTSIPPVI HTTGNELVMR FYADFFMEAK
GFRAFWTTDP TLPAPTEPPV PPNPWDDIPI EWPETCGRPA IPPMVNARIV NGEAAKAHSW
PWQVSMQVWP KSITSCPVTP YTSSAHLSTH ANVYLRYHQL QRWQMCLGKH NLTLSEPGQQ
CFGVQGIYRH KGFNYPTSPT VEFDIALVRL DGEVTPSDHV HFACLPPIEE VLPEGKTCYA
TGWGDETGNF SAPKASETLN QVALPVVPYD TCKRMDYWWF QVKSSMICAG YNLPDELKSV
CQGDSGGPLV CQDGPTGPWE VHGITSFGPI GCIMNKKPSV FTRTSAYLPW IENIMRKDSY
DGITSGCGGL KEQTGTEGVL SSMNHPQGYE NGARCQWNIV VPAGKRVHLH FDTFSLEESQ
LCLSDSVSIS DSLGSLGTHC SISPPADLVA VGATLTVHFS SNDRVVDTGF KATWRAVDPA
DISNLVGCGG EFVGQQGELQ SPNWPNNYPD QAACTWTISS PSAKSLHIVF TDFELQAVNI
LGKCVDFVEV FDAAGQSQGQ FCGFGPPKLT VTGDRATVRF RTNKEVQGKG FRGYWTTDPN
VFPTSGKNHM LNNDIIVVNY NYRTVNCS
//
