ID A0A3B4D0X1_PYGNA Unreviewed; 1426 AA.
AC A0A3B4D0X1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 {ECO:0000313|Ensembl:ENSPNAP00000017245.1};
GN Name=PREX1 {ECO:0000313|Ensembl:ENSPNAP00000017245.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000017245.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000017245.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSPNAT00000025967.1; ENSPNAP00000017245.1; ENSPNAG00000006762.1.
DR GeneTree; ENSGT00940000159925; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 1..65
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 96..216
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 246..320
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 353..421
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 449..496
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 533..593
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 898..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 933..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 48..75
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 898..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1426 AA; 161518 MW; 9166D4FC69BBE520 CRC64;
MLLGGKKSTD VPLEGYLLSP IQRICKYPLL LKELLKRTPK KHVDYPTVEE ALQAMKEVCS
NINETKRQME KLEALEQLQS HIEGWEGTNL TDICTELLLH GNLLKISAGN IQERVFFLFD
NLLVYCKRKS RVSGKKSTKR TKSINGPLYV FRGRINTEVM EVENVEDGTA DYHSNNYTVT
NGWKIHNTAK NKWFVCMAKN AEDKQKWLDA ILKEREQRES LKLGMERDAY VMIAEKGEKL
YHMMMTKSRH LIKDRRRKLS IVPKCFLGNE FVAWLLETGE ISKPEEGINL GQALLENGLI
HHVSDKHQFK NEQVLYRFRY DDGTYKARSE MEDIVSKGVR LYCRLHSLFT PVIKDRDHHL
KTFKSVLPAS KLVDWLLSQG DSATREDAVT LGVGLCNNGF MHHVLEKSEF KDESQFFRFY
ADEETEGTST KSKQLRNDFK LIENILVKSL LIHPEEEDYG FEIEEKNKAI VVKSVTRGSY
AEMAGLQAGR KIYSINEDLV FLRPFSEVET MINQSFCIRR SLRLLVATKN KELVKVPDCS
DGLSFKLSGS APPYVYAVKK GSEAAAAGLQ PGQCVLKVNG ANMSQSSYKE VLEHFSSYQP
EEDSCLSENS SDAEENDPVR GLERLSLSAD APLVNLMVDN MHLEHGVVYD YVSSAGIKHH
VLEKMVEPKG CFSLAAKILE AFAKDDNHFV TSCSQLIAQS ERVVSMPQYE FRNICDTKLE
SIQKRICNYR QFAEELQNKA SPTFKQASTK SHALSCMDFV PTNCHLNLMQ VSCPKSSTSA
GRAFSIRFGR KNSFFGLDPD QANLNPMSHT VHCVTSMAAP SWGCHGLDEE LEGGEGNVDV
SRRHTQGEGG LSFLLKQEDT ESQDNYICLY NRLDVAVREM KLYVAQIDVL LSSITGPIQP
QGSEPPSFDS VPSASPGPEE SSQSKRVCFK VNEDDQEDSG HDTMSYRDSY SECNSNRDSV
LSYTSVRSNS SYLGSDEMGS GDELPCDMQI PLDKQDKLHG CLEHLFNQVD SINSLLKGPV
MSKACEETKH FHPDHNQPEF RHTDDWTARC RYVLHKNIQE DPWNLPSSIK NLVDSLHRFV
EDTELQLRRD VIFCQALVGA LCALAEQLVW ALNLRFNNNG EYEDDSKEVS RKWLEQISAI
GVLFNFQSTL SPHVRDERTM LEDTKAALVD LDKVTVLFRP LENECLVANT PVHYQVEGSR
QAIRVTLYLD SCHFSELPTR LQNGGSLKLH SVLFTRALER PEGVPAQDFV EMEEFQQRIN
AVSLEKVKFY YRRLRAFYLE KSNLPSESNS TAMKIDQLLR PLNTLDDLCR LMQTYMNVRP
SAAGHPSGVS VLLVSSELCS RLGACNITMC ATGMQRCTLT VSLEQAMILA RNHGLMPRCF
MQAMDIMRKQ GTRVEISAKN LKVMDQMPTF APRLFKLCLP PSDGDL
//
