ID A0A3B4D0X9_PYGNA Unreviewed; 249 AA.
AC A0A3B4D0X9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=MICOS complex subunit mic25a-like {ECO:0000313|Ensembl:ENSPNAP00000016504.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000016504.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000016504.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane.
CC {ECO:0000256|ARBA:ARBA00002689}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00034476}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00034476}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic19 family. Metazoan
CC Mic25 subfamily. {ECO:0000256|ARBA:ARBA00034480}.
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DR RefSeq; XP_017549653.1; XM_017694164.1.
DR AlphaFoldDB; A0A3B4D0X9; -.
DR Ensembl; ENSPNAT00000025020.1; ENSPNAP00000016504.1; ENSPNAG00000022678.1.
DR GeneID; 108425484; -.
DR CTD; 449542; -.
DR GeneTree; ENSGT00390000000903; -.
DR OMA; CYRDHAH; -.
DR OrthoDB; 3383910at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR InterPro; IPR007964; MIC19/MIC25.
DR InterPro; IPR042860; MIC25.
DR PANTHER; PTHR47609; MICOS COMPLEX SUBUNIT MIC25; 1.
DR PANTHER; PTHR47609:SF1; MICOS COMPLEX SUBUNIT MIC25; 1.
DR Pfam; PF05300; MIC19_MIC25; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT REGION 26..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 249 AA; 28566 MW; C4A28E2316665896 CRC64;
MGSGESTTRK VSFGLDEDER VRILRGVKLS EDVLQRMRDA SQTPVSNKEN PGQQAKPQAP
SARTQPSKPQ QSPQFGSAAS DNREELKRRY EREQAIIQEE LARIARKERE AARQDITRAV
QRERLQTLQE SEKAKQLPAA EMDVWGKQLE KKEAELKALD AFYREQIAQL EKRNLDHFKT
SVEQFHAAAN RSEANIKPRC MEPVCTNLQA QILLCYRENR NQTLRCSDLA KEYMQCIDAA
KKNLLVNRG
//
