ID A0A3B4D107_PYGNA Unreviewed; 1538 AA.
AC A0A3B4D107;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Brain-specific angiogenesis inhibitor 1-like {ECO:0000313|Ensembl:ENSPNAP00000016746.1};
GN Name=ADGRB1 {ECO:0000313|Ensembl:ENSPNAP00000016746.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000016746.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000016746.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017567068.1; XM_017711579.1.
DR STRING; 42514.ENSPNAP00000016746; -.
DR Ensembl; ENSPNAT00000025323.1; ENSPNAP00000016746.1; ENSPNAG00000022990.1.
DR GeneID; 108435612; -.
DR GeneTree; ENSGT00940000157432; -.
DR OMA; QNGHTQR; -.
DR OrthoDB; 4181250at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR12011:SF39; ADHESION G PROTEIN-COUPLED RECEPTOR B1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF00090; TSP_1; 5.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1538
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017481779"
FT TRANSMEM 906..931
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 943..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 974..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1013..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1052..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1096..1118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 535..605
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 908..1149
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1166..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1443..1504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1455..1473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1538 AA; 170374 MW; 50DF18837DFAD16C CRC64;
MEWRPLSFTG LSLALCVCIF LGLTYATPSG PASATCATLE QSRFFGLFSS KTALPSAPCS
WTLQNPDPRR YTVYMKITKP TESCTPRQIK TFQFDSFLET SRTYLGMESF DEVVRLCDAS
SSVAYLESSK QFLQVRKVVP RIGTEMLVEE EGTDDEGRQF SAEFLVVGKR NPSVPACEML
CKWLEDCLAT STHGNPCGIM ATPCQCWEPP KRRPGGCYRG GVYMDKCTPT IRDSNRDAEI
MKGWSNWGRW SECSSECGGG IQVRSRACQP ENGICEGVVE EGRSCNPQPC IGKVRQRSQA
LRSIIGQRRD NGEETSLLQA PQPDANQDQW SSWSACSVTC GEGWQSRTRN CMTSAHSTLC
TGPLRENRPC NNSIVCPVNG AWDEWAPWSL CSSTCGRGYR DRVRVCKPPN NGGEPCRGPS
KQTKFCNIAV CPVDGSWNEW SGWSACSASC SNGTRQRTRE CNGPSYGGSE CRGDWREINN
CFLRDCPVDG RWLSWSSWGS CSKTCGGGSQ QRQRVCEGPF FGGEPCVGDK SELRRCNEKR
CPEPHEICVE ENYGSVVWKR TPAGDTAAIP CPSDATGMVI RRCTLDAVGL AFWENPTYIK
CISKEYQDIQ ALAREHFSKS QKGLLVDGVS EMLSRLRMTS NDGTKYSGDL LAVMEVLRNT
TEIFRGSGYS LSNADVENYA QTISNLLKEE HHGKWEETQL MGGSIKEFFS LIEDFIDMIG
KQMRDFQDIY EVTENLELSI QKRPKTMTSD VTFPMKGWRG MMEWVRNSEE KIVVSRNALS
LDVPGAEDST GFVTGIVLYR NLGPILSLQS NSTLLNSKIV TITVKPNPGF LSAPVEIEFP
HLNNGTINET CIAWDESETA SLLGSWSARG CRALALDSKT KCVCDSLSTF AILARPNPDS
NMDKNLLPSV TMIVGCGVSS LTLLLLIIIY VSVWKYIRSE RSVILINFCL SIICSNALIL
IGQTQARNKV MCTLVAAFLH FFFLSSFCWV LTEAWQSYMA VTGRLRNRII RKRFLCLGWG
LPALVVAVSV GFTKAKGYGT VNYCWLSLEG GLLYSFVGPA AAVVLVNMVI GILVFNKLVS
KDGITDVKLK ERAGASLWSS CVVLPLLALT WMSAVLAITD RRSALFQILF AVFDSLEGFI
IVMVHCILRR EVQEAVKCRV VDRKDDGNGD SGSSLQNGHT QRLGEFEKDA DSNRPGGMKS
SSEEKMPPPQ MPLPMGPNFH TLPSNPSAKA HMQAMPEYSS HTLTLRREKG RGVDPTCGKP
VYVCDSDIFK QMDVDLARSQ AEGNGVDAGG YVLMPNTTST LRSKPKEELS STTKYNISVE
QLPQARLMHI SGGFAEPQAA YASRTLPADR LSVSYSEERD SPVQNLHNIS SESHVTSSLG
DTFDSMNSMM SKSETISTLS MSSLEVSEGR QKSRYAELDF EKIMHTRKRH QNMFQDLNRK
LHHAEKDRES PASDSKSVRW SVSSAGSDKT SHSDKQQAPG ERSWESMPRS QTSPPAWVRK
DLEPLQASPL ELPTVEWEKA GTTIPLVGQD IIDLQTEV
//
