ID   A0A3B4D1A9_PYGNA        Unreviewed;       512 AA.
AC   A0A3B4D1A9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=SH2 domain-containing protein {ECO:0000259|PROSITE:PS50001};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000017318.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000017318.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4D1A9; -.
DR   STRING; 42514.ENSPNAP00000017318; -.
DR   Ensembl; ENSPNAT00000026091.1; ENSPNAP00000017318.1; ENSPNAG00000003775.1.
DR   GeneTree; ENSGT00940000156314; -.
DR   Proteomes; UP000261440; Unplaced.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF5; SUPPRESSOR OF CYTOKINE-SIGNALING 7; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN          408..489
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          12..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          293..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..202
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..339
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  54886 MW;  26B8A5789EB1A65B CRC64;
     FGFRHRIRRR SGGFRAGLDG PGPGQPGLGD AGERSSSLEA PAQRFEWSPV FRLTKVSREV
     SESLCQKHRL ISDAPDWSPL ADQLGTTTAR KPSSTAAVSP DLQDPVLKLA RRLGELGKGD
     VLQKDGDVPL CTCQNVPGAQ PGEDPSETSD ALLVLEGLGA QGEMGKAGCR DGSEGDTGAQ
     SAPQQSGANA GQEQHQTFSS SSLSGLMNQV HRLTREACLA LQVGDEVLRF TAALAVQDAA
     ANVQAPLSRP PTPKHVGSPL TFAACSRERD RAGQRKSRKG SLKVCLSKLF RTKSSGSAGS
     SSSVGHAADK RPSLASSTSS GGSLVDVWGS SSTDPDTGSR PQLARPRSAY SPVPFTDTFL
     RSVPRPLPLQ PDSQSTATVA QRPLLFPLSR PDSSSFATSL RELEKCGWYW GPMNWEDAEM
     KLKGKADGSF LVRDSSDPRY ILSLSFRSQG ITHHTRMEHY RGTTPCGTNC NYKIHHTSKG
     FQSPIQIIEF RCSSHFHGHR CIKSSVNSSV VP
//