ID A0A3B4D1G8_PYGNA Unreviewed; 853 AA.
AC A0A3B4D1G8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Potassium voltage-gated channel subfamily B member 2 {ECO:0000256|ARBA:ARBA00015830};
GN Name=KCNB2 {ECO:0000313|Ensembl:ENSPNAP00000017420.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000017420.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000017420.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}.
CC -!- SIMILARITY: Belongs to the potassium channel family. B (Shab) (TC
CC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00009411}.
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DR RefSeq; XP_017551625.1; XM_017696136.1.
DR AlphaFoldDB; A0A3B4D1G8; -.
DR STRING; 42514.ENSPNAP00000017420; -.
DR Ensembl; ENSPNAT00000026209.1; ENSPNAP00000017420.1; ENSPNAG00000023681.1.
DR GeneID; 108426548; -.
DR CTD; 566883; -.
DR GeneTree; ENSGT00940000161902; -.
DR OMA; HENSRFT; -.
DR OrthoDB; 1478695at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18412; BTB_POZ_KCNB2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003973; K_chnl_volt-dep_Kv2.
DR InterPro; IPR005826; K_chnl_volt-dep_Kv2.2.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF134; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 2; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03521; Kv2channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01515; KV22CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR PRINTS; PR01495; SHABCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 191..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..144
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 95817 MW; 711C6BF030455A97 CRC64;
MSDNSGLGVP KPNARSSTSL PPEPIEIIRT KARSRRVRLN VGGLNHEVLW RTLDRLPRTR
LGKLRDCNTH ESLMEVCDDY SLNENEYFFD RHPGAFTSIL NFYRTGKLHM MEEMCALSFG
QELDYWGIDE IYLESCCQAR YHQKKEQMNE ELRREAETLR ERDGEGEFDN TCCSEKRKKL
WDLLEKPNSS VAAKILAIIS ILFIILSTIA LSLNTLPELQ ETDEFGQPND NPQLAHVEAV
CIAWFTMEYL LRFLSSPNKW KFFKGPLNVI DLLAILPYYV TIFLTESNKS VLQFQNMRRV
VQIFRIMRIL RILKLARHST GLQSLGFTLR RSYNELGLLI LFLAMGIMIF SSLVFFAEKD
EDATKFTSIP ASFWWATITM TTVGYGDIYP QTLLGKIVGG LCCIAGVLVI ALPIPIIVNN
FSEFYKEQKR QEKAIKRREA LERAKRNGSI VSMNLKDAFA RSMELMDVVV EKSEDKPSLD
NHLSPSRWGI PKRTTSDASL RSLKKKSLES SSQECIKTSS PQHLNAQKLE EMYNQMTKAQ
SFSDLNTTAS TEPADDPKQE VELEMKNMPE PQPKERTIPD VRSISSVDSF ASCTAEFGET
DKSVPTLGTA AQLQQSYPEV PPLVEEKQLM PCNTTKNAVG LSESNRFELE QDNQPSIQVS
SREDGENFAQ FVENTRSCLP GTNPAKMKSL KVNFLGTLEE APLTPPNTSS PQDISSSLLE
DDSPDGESSP LFSDSEPLAT IPEEGLVLSP IILAGDFHPE QTALLLPDDG ESHGFHQSSD
NHEEKHLMEV AGAAVPLPKL SSQNCTQDVV SDNGQDKQDS NQSGHKVENH MFTPEIHLMP
GDGNLSPTCE TSM
//
