ID A0A3B4D2S6_PYGNA Unreviewed; 1160 AA.
AC A0A3B4D2S6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Zinc fingers and homeoboxes 3 {ECO:0000313|Ensembl:ENSPNAP00000017376.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000017376.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000017376.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the ZHX family. {ECO:0000256|ARBA:ARBA00007440}.
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DR RefSeq; XP_017553716.1; XM_017698227.1.
DR AlphaFoldDB; A0A3B4D2S6; -.
DR STRING; 42514.ENSPNAP00000017376; -.
DR Ensembl; ENSPNAT00000026163.1; ENSPNAP00000017376.1; ENSPNAG00000023616.1.
DR GeneID; 108427762; -.
DR CTD; 386659; -.
DR GeneTree; ENSGT00950000182893; -.
DR OMA; YYVTHKM; -.
DR OrthoDB; 5350395at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 5.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 5.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR041057; ZHX_Znf_C2H2.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR PANTHER; PTHR15467:SF6; ZINC FINGERS AND HOMEOBOXES PROTEIN 3; 1.
DR PANTHER; PTHR15467; ZINC-FINGERS AND HOMEOBOXES RELATED; 1.
DR Pfam; PF00046; Homeodomain; 3.
DR Pfam; PF18387; zf_C2H2_ZHX; 1.
DR SMART; SM00389; HOX; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 4.
DR PROSITE; PS50071; HOMEOBOX_2; 4.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 308..351
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 657..707
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 791..839
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 960..1020
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 310..352
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 659..708
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 793..840
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 962..1021
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 263..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..968
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..848
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..863
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1160 AA; 125234 MW; E5008B7F136C228F CRC64;
MASKRKSTIP CMIPVKTLLL QDELEQGRHS PLCKESSFFH KEEPNAKGFQ TLDESPGHEA
GDAHKDGGTY TCRPCNFETQ DLNLFLDHVY SGHPEFRTDP TFLCVDCGVS AAKFEGLALH
NARVHPSTMT TTLQLKKKDR KVTVEQNLIV GLGESTSSKE SEISITKTPI MKMLKGKSES
KRIVVSHPGA DEPAATTVKQ VETKESPAVT VTHVPTIVHN GAASKVTLPS AIQIVNGSGA
LPLLKTANTQ VVSVVQNRSL SQQSTLSSST SSSSSSSSAS SSKNLPKVMI PLSSIPTYNA
SMDNSSFLKT SFSKFPYPTK AELCYLTVVT KYPEEQIKIW FTAQRLKQGI SWSPEEIEDA
RRKMFNTIIQ TAPPAGQQQC QTHHSTPQQT IAVLPASLGT TGIPHILQGS LVGQGGVIVT
QPMMANGIQV SSAPVALAVT PKPQAAAKPM MQAKPAAALV ADKGLSMVVG SVGSSNSGNY
TISNSSSGGS SSSSSSSSSI TSSIISSLST NSSHASVISI GSSSSGKINS NSNSKASIPS
TNGKSSASSS SNAKMVTDNK NSTNVKANTA KSSVDSKGST DVKGNTKNNE RENKSSCSSS
SSNSSSPSVT ASSSPAMTAT ADSTPSKSES PSPVSANSRT LPTSSFLDPS FYKAKKSQEQ
LLALKESFLI SQFPSQEEVD RLTNLTGLTV REVRKWFSDR RYHFRNLKGS RSSTGGQTSA
ASSASSTASA STAVGDVSDN AASTERPKTP QKMPLSPSRQ QQTTPPTPTR RPPRPPSPDF
TAIRYKEREP HQVRALEASF AQDPDPSGEE VDRLRAETKM TRREIHGWFA DRRRRVAAEK
KKEELERAER EDEDDEDVEK EKEEGGEVSE KGKKDLEKEV ADIKEDIEES SSETGQQVKD
EKQKEDASGT APKVNPIKIN LKMLKVTESN GKGEMEGSPQ PETTKVPPVA SQTSTPSSQP
PQTAYRGKKT PEQLHLLKQA FARTHWPSSP LYNELIAKTG LPRPEVVRWF GDCRYVLKNG
QLKWLESYQS MVDEEDFQKG NITLLQEHLN TNGKLVESQL EELAKSSGLS EELVRRWFTR
QTKAALPSEE AKSEDAEAME MKPSPSAAKG KTNLKSVQQD EGDVKDEQME QSVTNLTLKD
QTTKKTTTGE TDTGAKQESE
//
