ID A0A3B4D2T5_PYGNA Unreviewed; 591 AA.
AC A0A3B4D2T5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Merlin {ECO:0000313|Ensembl:ENSPNAP00000017860.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000017860.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000017860.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_017560541.1; XM_017705052.1.
DR AlphaFoldDB; A0A3B4D2T5; -.
DR STRING; 42514.ENSPNAP00000017860; -.
DR Ensembl; ENSPNAT00000026823.1; ENSPNAP00000017860.1; ENSPNAG00000024249.1.
DR GeneID; 108431713; -.
DR CTD; 561184; -.
DR GeneTree; ENSGT01020000230354; -.
DR OMA; HDLYMKR; -.
DR OrthoDB; 5476297at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13194; FERM_C_ERM; 1.
DR CDD; cd17186; FERM_F1_Merlin; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR041789; ERM_FERM_C.
DR InterPro; IPR046810; ERM_helical.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23281:SF23; MERLIN; 1.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF20492; ERM_helical; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PIRSF; PIRSF002305; ERM; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT DOMAIN 22..311
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 554..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 313..471
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 515..552
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 76..79
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol)"
FT /ligand_id="ChEBI:CHEBI:57880"
FT /evidence="ECO:0000256|PIRSR:PIRSR002305-1"
FT BINDING 294
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol)"
FT /ligand_id="ChEBI:CHEBI:57880"
FT /evidence="ECO:0000256|PIRSR:PIRSR002305-1"
SQ SEQUENCE 591 AA; 69211 MW; 921E4DCF27BFD311 CRC64;
MASVLASKMG LNSLRRRQAK TFNVRIVTMD ADLEFSCEVK WKGKDLFELV CRTLGLRETW
FFGLQYNVKD TVAWLKMDKK VLDQDVPKEE PIVLNFLAKF YPENAEEELV QDITQHLFFL
QVKKKILEEE VYCPPEASVL LASYAVQAKY GDYDPSVHKP GFLAQEELLP KRVINLYQMT
AEMWEERITA CYAEHRGRTR DEAEMEYLKI AQDLEMYGVN YFFIRNKKGT DLLLGVDALG
LHIYDPENKL TPKISFPWNE IRNISYSDKE FAIKPLDKKA DVFKFNSSKL RVNKLILQLC
IGNHDLFMRR HRVDSLEVQQ MKAQAREEKA RKQMERQRLE REKHLREEAE RARDELERRL
IQLQDEAHMA NEALLRSEET ADLLAEKAQI AEEEAKLLAQ KAAEAEQEIQ RIKVTAIRSE
EEKRLIEQKM LETEMLALKM AEESERRAKE ADQLKQDLQE ARESERRAKY KLLEITSKSP
YSAASLSPSA LPPDLSFSTE NLSFDFKDTD MKRLSMEIEK EKVEYMEKSK HLQEQLNELK
TEIESLKLKE RETPLDILHN ENTERGTSKQ SNFKKLTLQS TKSRVAFFEE L
//
