ID A0A3B4D314_PYGNA Unreviewed; 1051 AA.
AC A0A3B4D314;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Disabled homolog 2-interacting protein-like {ECO:0000313|Ensembl:ENSPNAP00000017935.1};
GN Name=DAB2IP {ECO:0000313|Ensembl:ENSPNAP00000017935.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000017935.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000017935.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4D314; -.
DR Ensembl; ENSPNAT00000038753.1; ENSPNAP00000017935.1; ENSPNAG00000024529.1.
DR GeneTree; ENSGT00940000155853; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF26; DISABLED HOMOLOG 2-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT DOMAIN 1..78
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 69..187
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 247..439
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 597..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 897..963
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 993..1020
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 597..656
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..755
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1051 AA; 117642 MW; 9C0A8AB5EB3FD556 CRC64;
MPRLKESRSH ESLLSPSSAV EALDLSMEEE VLIKPVHSSI LGQDFCFEVT TSTGSKCFSC
RSAAEREKWM ENLRRAVHPN KDNSRRVENM LKCWIIEAKD LPAKKKYFCE LCLDDTLYAR
TTCKLKTDNV FWGEHFEFNN LPSVKSITVH LYKETDKKKK KDKNNYIGLV NVPIVAVTGR
QFVEKWYTVS TPNPNKGKTP GPMVRMKCRY QSMSILPMEL YKEFAEYITN NYMLLCSILE
PALSVKSKEE MACALVHILQ STGKAKDFLT DLMMSEVDRC GDNEHLIFRE NTLATKAIEE
YLKLVGQKYL QDALGEFIKA LYESDENCEV DPSKCSSSDL PEHQGNLKMC CELAFCKIIN
SYCVFPRELK EVFASWRQEC GNRGRPDISE RLISASLFLR FLCPAIMSPS LFDLMQEYPD
DRTARTLTLI AKVTQNLANF TKFGSKEEYM SFMNQFLEHE WTNMQRFLLE ISNPETISNT
AGFEGYIDLG RELSTLHSLL SEAVTQLDQS TAAKLGPLVR ILRDVNMALT NPTGVPVASP
TERVGSPSLP SCSVSTGLQK LVMDTELTGL VDFTRLPSPT PENKDLFFVT RNSVIQPSPA
RSSSYSEANE PDIQLPNGSK SLSMVDLQDS RSLESGPCTS SSDPANDLQG SGAWNAPTLK
GNMAAGPTLR KTGQTPTTPS TETAPGRPQL LAPLSFQNPV YQMAAGLPVS PRGGGTADSG
SECHSSISSQ GNVEDSATTG AKHHSSDEFV RRSGEFTRRQ LSLTETQHQA NVPRQNSAGP
QRRIDQPPPP TITRGRTPPS MLNTAPYPRP SSGSMMSSSP DWPSGGARLR QQSSSSKGDS
PETKQRTLHK QAPSPVNPGA LDRTAAWLLN MNVQYLEQEG IDPDSRHRED LPNKDELTQT
EKEIAMLQER LRLSAKKLEE YEVRLQGQDE QTQKMLLEYQ ARLEDAEDRL RRQQEDKELQ
MKSIITRLMS VEEELKKDHA DMQAIVDSKQ KIIEAQEKRI ASLDAANARL MSALSQLKER
YSMQTRNGIS PTNPSKLQIT ENGEFRNSSN C
//