ID A0A3B4D3Q5_PYGNA Unreviewed; 481 AA.
AC A0A3B4D3Q5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Probable G-protein coupled receptor 61 {ECO:0000313|Ensembl:ENSPNAP00000018180.1};
GN Name=GPR61 {ECO:0000313|Ensembl:ENSPNAP00000018180.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000018180.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000018180.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; XP_017544409.1; XM_017688920.1.
DR AlphaFoldDB; A0A3B4D3Q5; -.
DR Ensembl; ENSPNAT00000027279.1; ENSPNAP00000018180.1; ENSPNAG00000024524.1.
DR GeneID; 108415872; -.
DR GeneTree; ENSGT00950000182998; -.
DR OMA; WMETPRR; -.
DR OrthoDB; 3036305at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15220; 7tmA_GPR61_GPR62-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR22752; G PROTEIN-COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22752:SF5; G-PROTEIN COUPLED RECEPTOR 61; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..369
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 263..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..449
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 481 AA; 52295 MW; 615657ADB0490310 CRC64;
MDPQRNSSQM PSWLANQSLS GVPEGGTMSQ SLALLAMLLM DVLAVAGNTA VMLVIARTPQ
LRKFVFVFHL CLVDLLAALV LMPLGMMGVM SGSSRTFLGS EALCRSYLFL SVCLVSAAIL
SICAINVERY YYVLHPMRYE VRMTLGLVGG VLGGIWMKAL LMSVLPLLAW VLQGGRGHML
EPGVSGVDGG GVTIPASHPP AHTHRRCSLH WSGGGANRVA FMVLFALVYF LCPLLLILVV
YCSMFKVARV AAMQHGPMPT WTETLRRRRS ESLSSRSTMV TSSGSGSRSD STTGTGTGAC
GTPQRPFGGG KAAAILAAMG GQFLFCWLPY FSFHLYSALA SLQPASLAPL EDVVTWIGYL
CFTSNPFFYG CLNRQIRQEL SKHLPFLFRP PAGDEQEHLP SRDGSIQENF MQFLQGTGCN
LENPDSQNVS SPKSAPLRPP PPLPRSQPIP IDFRIPGQIA EETSEFLEQH QIKNNLIIPD
S
//
