ID   A0A3B4D442_PYGNA        Unreviewed;        72 AA.
AC   A0A3B4D442;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Copper transport protein ATOX1 {ECO:0000256|ARBA:ARBA00040962};
DE   AltName: Full=Metal transport protein ATX1 {ECO:0000256|ARBA:ARBA00043201};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000018248.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000018248.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Binds and deliver cytosolic copper to the copper ATPase
CC       proteins. May be important in cellular antioxidant defense.
CC       {ECO:0000256|ARBA:ARBA00037651}.
CC   -!- SIMILARITY: Belongs to the ATX1 family.
CC       {ECO:0000256|ARBA:ARBA00038171}.
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DR   AlphaFoldDB; A0A3B4D442; -.
DR   STRING; 42514.ENSPNAP00000018248; -.
DR   Ensembl; ENSPNAT00000027379.1; ENSPNAP00000018248.1; ENSPNAG00000024625.1.
DR   GeneTree; ENSGT00940000163780; -.
DR   OMA; MTHTYKF; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR   CDD; cd00371; HMA; 1.
DR   Gene3D; 3.30.70.100; -; 1.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   PANTHER; PTHR46365; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR   PANTHER; PTHR46365:SF1; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR   Pfam; PF00403; HMA; 1.
DR   SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          6..67
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
SQ   SEQUENCE   72 AA;  8140 MW;  7D15964AEB2FEBE1 CRC64;
     MGKKRSLTHE FFVDMTCEGC SGAVTRVLKK IDVKFDIDLP NKKVFIESDK DKDVLLETLK
     KTGKTVTYIG TK
//