ID A0A3B4D4W0_PYGNA Unreviewed; 1415 AA.
AC A0A3B4D4W0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRIN2C {ECO:0000313|Ensembl:ENSPNAP00000017939.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000017939.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000017939.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00034104,
CC ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034104}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR RefSeq; XP_017561386.1; XM_017705897.1.
DR STRING; 42514.ENSPNAP00000017939; -.
DR Ensembl; ENSPNAT00000026936.1; ENSPNAP00000017939.1; ENSPNAG00000005556.1.
DR GeneID; 108432208; -.
DR CTD; 100003342; -.
DR GeneTree; ENSGT00940000156964; -.
DR OMA; FPIHYGD; -.
DR OrthoDB; 1034721at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004970; F:glutamate-gated receptor activity; IEA:UniProt.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProt.
DR CDD; cd06378; PBP1_iGluR_NMDA_NR2; 1.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR018884; NMDAR2_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF405; GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF10565; NMDAR2_C; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 31..1415
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027148724"
FT TRANSMEM 564..587
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 639..662
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 828..850
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 451..806
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 458..510
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 1090..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1361..1387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1415 AA; 158536 MW; 9A59324E248B62F7 CRC64;
MGVRLGRLSD TLWPPLLLLL LLCALPSCQG RPFTMVEPTV NVAVVFSGSA YQLEIKGRLS
RENFLDLPME VNPITVLVNN TNPRALLTRI CDTLAANRVH GVVFEDNIGS EAVAQILDFI
STQTAVPIVG ISGGSAVVLP HKGDGSTFLQ LGSSIEQQIN GMFKVMEEYN WDSFVVVTSQ
YPGYEAFVDY IRSFTDTSYF LWELQDVLTF DMSADGMNDL RARRLLQQID AQVLLVYCSH
DEAQYLFSMA KEVGLLGPGY IWIIPSLAVG NPNIPPPDSF PVGLISIITD RWKMSLRNRV
RDGVAIVVKG VESFRKHRGF IPDGHTDCQT PLRPDTNDTL FKHMLNVSWE HTDFSFNSDG
YLVNPSMIII TLDRERQWDK VGSYESGILQ MRYPVWPRYG TYMEPVSDNR HLTVATLEER
PFVIVEAVDP ITGTCLSNTV PCRRQSNKTE TIIGHTEPYT KLCCKGFCID ILKKLSRNIK
FSYDLYLVTN GKHGKLVRGV WNGMIGEVVY KRADMAIGSL TINEERSEII DFSVPFVETG
ISVMVARSNG TVSPSAFLEP YSPAVWVMMF VMCLTVVAVT VFVFEYFSPV GYNRSLVSAK
DPGGPTFTIG KSVWLLWGIV FNNSVPIENP KGTTSKIMVL VWAFFAVIFL ASYTANLAAF
MIQEQYIDTV SGLSDKKFQK PQEQYPPFRF GTVPNGSTER NIRSNYPEMH SHMVKYNQKG
VEDALNSLKT GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IALQKGSRWK
RPIDLALLQF LADGDTAKLQ TVWLTGICRN EKKEVMSSKL DIDNMAGVFY MLLVAMGLSL
LVFAWEHLLY WKLRHSVRKS ERLDFLLAIS RGIYSCFNGV EDTDRNGSMQ SPDVTTNYTQ
ANMLKMLKTA KDIVSSARVE NSLDNATKTI ENLSRRGPDA TKPCLPTRLI STDSSHGRLP
YISSVTDNHA PYPHTPTFPL HYGDSGTQPL LEKPRVVTRP TPLRYTLPAR TSHHHIYERT
LPISSLSSPH IAMRDPPPPT APKPHHSGRF YMDSQACHQT SPFLPYREFH VPDIYVEHQE
PSGSRKLYAE GLGRKKRSHS YVAPSPETRR RNDYDEPTSC LAELRANHLL DNHAHTTPCM
GSHYQRPSGS CNSCMKPYLE PEMDDVPLLG KEKLNRRASF LRATWGGDRI RHLDEKPSTS
ASSSSRINMP DLFPRVVVAN PKPSKMYSSA GNNLCYNMAV EPAYLDPAHM GSYPYKPQKL
KYSQSTRLPS YREAILQNAA ALRRSSSTVV HRHYSTYLNS YTDLPVYVGP LAQGPAHFYD
HSKDMCHLFP CVNHCPDDAA LLPRLSGRPV MYQNTAFGGY EGAGRSRDEP PLQPLHTLPA
SSGNRDRRQV LVARRVNSPY VPKPWGRVSS LESEV
//
