ID   A0A3B4D570_PYGNA        Unreviewed;       708 AA.
AC   A0A3B4D570;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Exostosin-1b {ECO:0000313|Ensembl:ENSPNAP00000018054.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000018054.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000018054.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004648}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC       {ECO:0000256|ARBA:ARBA00010271}.
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DR   AlphaFoldDB; A0A3B4D570; -.
DR   Ensembl; ENSPNAT00000027122.1; ENSPNAP00000018054.1; ENSPNAG00000024449.1.
DR   GeneTree; ENSGT00940000155321; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050508; F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050509; F:N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR004263; Exostosin.
DR   InterPro; IPR040911; Exostosin_GT47.
DR   InterPro; IPR015338; GT64.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR   PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR   Pfam; PF03016; Exostosin; 1.
DR   Pfam; PF09258; Glyco_transf_64; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           33..708
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5017456444"
FT   DOMAIN          109..350
FT                   /note="Exostosin GT47"
FT                   /evidence="ECO:0000259|Pfam:PF03016"
FT   DOMAIN          442..691
FT                   /note="Glycosyl transferase 64"
FT                   /evidence="ECO:0000259|Pfam:PF09258"
FT   REGION          31..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   708 AA;  81095 MW;  DDE077D3313546DC CRC64;
     MQAKKRYLIS LLTGASLVLL LYFGGVPGPA PATSRHERAR GGGGGGRRSG QPWPHASEPF
     QPFSPGDETD TEEYNAHVSP RQKREVHASV YRGKRCRMDS CFDFSLCRRN GFKVYVYPQQ
     KGEKISESYQ SILAAIEGSR FYTSDPSQAC LFVLSLDTLD RDQLSPHYVH NLKSKVQSLP
     LWNDGRNHLV FNLYSGTWPD YTEDLGFDIG QAMLAKASVS TENFRPGFDV SIPLFPKEHP
     RSGGERGHLR ANSIPPFRKY MLVFKGKRYL TGIGSDTRNA LYHVHNAEDV VLLTTCKHGK
     DWQKHKDARC DKDNAEYDKY DYREMLHNST FCLVPRGRRL GSFRFLEALQ IPSTVRSIHQ
     DKILALRQQT QFLWEAYFSS VEKIVLTTLE IIQDRVLQHT ARSSLMWNSH PGGLFTLPQY
     SSYLGDFPFY YAGLGIKPYP KFTAVIHAVT PLVSQSQPIL KLLVAVAKSQ YCAQIIVLWN
     CDKPLPAKHR WPATSVPVIV IEGENKVMSS RFQPYESIIT DAVLSLDEDT VLSTTEVDFA
     FTVWQSFPER IVGYPARSHF WDSNKERWGY TSKWTNDYSM VLTGAAIYHR YYHYLYTHFL
     PSSLKNMVDQ LANCEDILMN FLVSAVTKLP PIKVTQKKQY KETMMGQSSR ASRWADPDHF
     AQRQTCMNKF ASWFGGMPLV HSQMRLDPVL FKDQVSILRK KYREIERL
//