ID A0A3B4D662_PYGNA Unreviewed; 843 AA.
AC A0A3B4D662;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Very low density lipoprotein receptor {ECO:0000313|Ensembl:ENSPNAP00000019852.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000019852.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000019852.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR RefSeq; XP_017555725.1; XM_017700236.1.
DR AlphaFoldDB; A0A3B4D662; -.
DR Ensembl; ENSPNAT00000039685.1; ENSPNAP00000019852.1; ENSPNAG00000026791.1.
DR GeneID; 108428877; -.
DR CTD; 7436; -.
DR GeneTree; ENSGT00940000155460; -.
DR OMA; DEYACKN; -.
DR OrthoDB; 3918101at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..843
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017404441"
FT TRANSMEM 767..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..64
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 67..105
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 149..185
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 273..309
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 352..391
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 355..391
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 392..431
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 395..431
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 523..565
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 566..609
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 610..654
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 703..748
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DISULFID 29..41
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 36..54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 48..63
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 68..80
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 75..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 130..145
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 150..162
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 157..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 189..201
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 196..214
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 235..247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 242..260
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 254..269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 274..286
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 281..299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 293..308
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 322..340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 843 AA; 93181 MW; 8D4FB19FB8E0C0BA CRC64;
MLPSVLRLLL LLPVWLQQGS FAGGSRTECE PSQFQCGNGR CIPSVWQCDG DEDCSDGSDE
STCVRKTCAE ADFVCRNGQC IPKRWHCDGE PDCEDGSDES TEVCHTRTCR MNEFSCGVGS
TQCIPVFWKC DGEKDCDNGE DEINCGNITC APLEFTCSSG RCISRNFVCN SEDDCGDGSD
EQDCAPSSCG PTEFQCGNAT CIPGGWVCDD DVDCQDQSDE SPQRCGRNPT PPAKCSSSEI
QCASGECIHR KWRCDGDADC KDGSDEKNCP ARACRPDQFK CDDGSCIHGS RQCNGIRDCA
DGTDEVNCKN LTQCNGPDKF KCRSGECIEM SKVCNKARDC PDWSDEPIKE CNLNECLLNN
GGCSHLCRDM VIGYECGCTP GLQLIDRKTC GDINECLNPG ICSQICINLK GGYKCECHSG
YQMDPTTGVC KAVGKEPCLI FTNRRDIRKL GLERREYTQI VEQLRNTVAL DADFTQQRIF
WADLGQKAIF STVLDKRDDI GTYTKVIDNV QMPVGIAVDW IYKNIYWSDL GSKTIAVANF
NGTKRKVLFA GDLKEPASIA VDPLSGFLYW SDWGEPAKIE KSGMNGIDRQ VLVETDIQWP
NGITLDLIKS RLYWVDSKLH TLCSVDFNGD NRRKVLQSQD YLAHPFALTV FEDRVFWTDG
ESEAIYGANK FTGSDVTMLA NNLNEPQDII VYHELIQLSG TNWCNEKILN GGCSYMCLPA
PQINKHSPKY TCVCPEGQEL SSDGLRCRPE GNISTSIHEV KSAKGSAAAW AILPVLLLAM
AATGGYLMWR NWQLKNKKSM NFDNPVYLKT TEEDLNIDIS RHSASVGHTY PAISVVNTED
DLS
//
