ID A0A3B4D6I2_PYGNA Unreviewed; 1531 AA.
AC A0A3B4D6I2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Intersectin 1 {ECO:0000313|Ensembl:ENSPNAP00000019115.1};
GN Name=ITSN1 {ECO:0000313|Ensembl:ENSPNAP00000019115.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000019115.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000019115.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR Ensembl; ENSPNAT00000028732.1; ENSPNAP00000019115.1; ENSPNAG00000004518.1.
DR GeneTree; ENSGT00940000157065; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08375; C2_Intersectin; 1.
DR CDD; cd00052; EH; 2.
DR CDD; cd13264; PH_ITSN; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11987; SH3_Intersectin1_1; 1.
DR CDD; cd11989; SH3_Intersectin1_2; 1.
DR CDD; cd11993; SH3_Intersectin1_4; 1.
DR CDD; cd11995; SH3_Intersectin1_5; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032140; INTAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16617; INTAP; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 1..52
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 1..31
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 166..255
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 199..234
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 637..698
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 756..814
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 828..886
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 900..964
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 965..1024
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1047..1233
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1272..1381
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1389..1505
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 598..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 285..432
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 708..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1531 AA; 174698 MW; 9795A5951CC710B5 CRC64;
LAQIWALADL NNDGKMDMHE FSIAMKLIKL KLQGHPLPPT LPPSMKQPPL SIPPPSAFGK
CGMPSMGTMT GIPAVPPMPL PPLPPGVPGV GMSPPLVSSV TPPVPPMANG APSMIQPISG
FSHPGKRLST HMNTHWHIHP LNNLFLSPCS APAAPVPSDW AVPQSSRLKY RQLFNSHDKM
MSGHLTGPQA RTILMQSSLP QAQLATIWNL SDIDQDGKLT AEEFILAMHL IDMAMSGLPL
PPLLPPELLP PTFRSEYPPT LNAITKEEEK EAEKKLPVTF EDKKRENFER GNLELEKRRQ
ALLEQQRKEQ ERLAALEREE QERKERERQE QERRRQQELE KQLEKQRELE RQREEERRKE
IERREAAKRE LERQRQLEWE RNRRQELLTQ RNREQENIVL LKARKKTLEF ELEALNDKKS
QLEGKLQDIR FRLSTQRQEI ESTNKTRELR IAEITTLQQQ LQVPHPAELY HVQCLEQLRQ
QLIITFDLFV FIGDSLSGLQ RAVEMKEATR QQLCEQLDAV EKETRSKLLE IDAFNTQLKV
LTKHSHKTQT CVQIDRQTDR HAHRQTVLVP LVLQLTYLVS HHALQELREI HNKQQRQKQK
ELEGDIIQPP LDSKPADLQE SRSVYKVPIS GLNQEKVRVV YYRTLYPFEA RSHDEITIQP
GDIVMVDESQ TGEPGWLGGE IKGKTGWFPA NYAEKIPESE VPLNLRASAT SSSPTQPTQP
SLSVPSGGQG RQRSAFTPAT LSGSSPSPVL GQGEKVEGLQ AQALYPWRAK KDNHLNFNKN
DVITVLEQQD MWWFGEVQGQ RGWFPKSYVK LISGPVRKSM SMAYSCFLFL FFYIAMYTYE
SSEQGDLTFQ QGDVITVLKK EGDWWTGTVA GKTGVFPSNY VKPKDSEGLG PAGKTGSLGK
KPEIAQVIAP YTATGAEQLT LAPGQLILIR KKNPGGWWEG ELQARGKKRQ IGWFPANYVK
LLSPSTMCQV IGMYDYVAQN DDELPFGKGQ IINVLSREDP DWWKGELNGS VGLFPSNYVK
LTTDTDPSQQ WCADLHLLDM LTPMERKRQG YIHELIVTEE NYVNDLQLVT ETFQKPLLES
ELLTEKEVAM IFVNWKELIM CNIKLLKALR VRKKMSGERM PVKMIGDILT AQLPHMQPYI
RFCSCQLNGA TLIQQKTDEV PDFKDFVKRL AMDPRCKGMP LSSFLLKPMQ RVTRYPLIIK
NILENTPESH PDHSHLRQAL EKAEELCSQV NEGVREKENS DRLEWIQAHV QCEGLSEQLV
FNSVTNCLGP RKFLHSGKLY KAKSNKELYG FLFNDFLLLT QVIKPLGSSA SDKVFSAKSH
LQYRMYKTPI FLNEVLVKLP TDPSGDEPIF HISHIDRVYT IRAESINERT AWVQKIKAAS
ELFIETEKKK REKAYLVRSQ RATGIGRLMV NIVEGIELKP CRSHGKSNPY CEVTMGSQCH
ITKTLQDTLN PKWNSNCQFF IKDLEQDVLC VTVFERDQFS PDDFLGRTEI RLADIKKDQG
SKGPITKRLL LHEVPTGEIV VRLDLQLFDE P
//
