ID   A0A3B4D7X8_PYGNA        Unreviewed;       365 AA.
AC   A0A3B4D7X8;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=B2 bradykinin receptor {ECO:0000256|ARBA:ARBA00013512};
GN   Name=BDKRB2 {ECO:0000313|Ensembl:ENSPNAP00000019533.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000019533.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000019533.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for bradykinin. It is associated with G proteins
CC       that activate a phosphatidylinositol-calcium second messenger system.
CC       {ECO:0000256|ARBA:ARBA00025423}.
CC   -!- SUBUNIT: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
CC       {ECO:0000256|ARBA:ARBA00025954}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   AlphaFoldDB; A0A3B4D7X8; -.
DR   STRING; 42514.ENSPNAP00000019533; -.
DR   Ensembl; ENSPNAT00000029412.1; ENSPNAP00000019533.1; ENSPNAG00000026130.1.
DR   GeneTree; ENSGT01030000234534; -.
DR   OMA; ISMNYIC; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004947; F:bradykinin receptor activity; IEA:InterPro.
DR   GO; GO:0006939; P:smooth muscle contraction; IEA:InterPro.
DR   GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR001504; Brdyknn_2_rcpt.
DR   InterPro; IPR000496; Brdyknn_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF948; B2 BRADYKININ RECEPTOR; 1.
DR   PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00425; BRADYKININR.
DR   PRINTS; PR00994; BRADYKINNB2R.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        51..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        84..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        126..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        165..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        216..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        255..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          62..318
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   365 AA;  41822 MW;  6AC005AB537820F6 CRC64;
     MSNWFIYYYV ERFSMELNLS VSLVPTVDSV AIDNCTYTEA WEWLSSLQPK FMALISILGV
     VGNGLVLCVF CLQQKPCTVA DIYLGNLAFA DLVMVLCLPF WAVTIAQDYQ WTFGQLLCKL
     VNTAISMNYF CSVLFLVLVS LDRYLALARP MNPSRLRRAA WAKRICLGIW LLGFLLSIPA
     FLFRTVSYIP DLDVHACILE FPHPRWRIQR NLTNNILGFV IPLPIIAFCT HHMVKALKDG
     SAGAHPSVRT ERRATHLVLT VLAIFLFCWT PFQVVRVLDT LDYFQLMPGC LFSHILDISI
     QLSTYLAYAN SSINPFLYVV VGKHFRRRAK GVCCYLMILT FILMNVYVYL FLMFIIGVKS
     YFNIE
//