ID A0A3B4D9J4_PYGNA Unreviewed; 661 AA.
AC A0A3B4D9J4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000021017.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000021017.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
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DR RefSeq; XP_017555665.1; XM_017700176.1.
DR STRING; 42514.ENSPNAP00000021017; -.
DR Ensembl; ENSPNAT00000040316.1; ENSPNAP00000036832.1; ENSPNAG00000027990.1.
DR Ensembl; ENSPNAT00000040317.1; ENSPNAP00000021017.1; ENSPNAG00000027990.1.
DR GeneID; 108428835; -.
DR CTD; 393854; -.
DR GeneTree; ENSGT00940000160004; -.
DR OMA; DSCFHNV; -.
DR OrthoDB; 2901840at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14645; DSP_DUSP8; 1.
DR CDD; cd01446; DSP_MapKP; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR048035; DUSP8_DSP.
DR InterPro; IPR008343; MKP.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR10159; DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR10159:SF108; DUAL SPECIFICITY PROTEIN PHOSPHATASE 8; 1.
DR Pfam; PF00782; DSPc; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR PRINTS; PR01764; MAPKPHPHTASE.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912}.
FT DOMAIN 23..138
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 160..302
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 222..283
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 307..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 71683 MW; 1C823D57281AAC11 CRC64;
MAGEKGRRSA MDIKRLAGLL QRGAGRLLVI DSRTFSEYNA SHVHGAVNVC CSKLVKRRLQ
QDKVSVTELL QPNGKVKVDL GRRQEVVVYD QSTKDAGQLS KDGFVHILLS KLDGTFHKVS
LLTGGFAAFS SCFPGLCEGK PVATLPMSLS QPCLPVANVG PTRILPHLYL GSQKDVLNKD
LMAQNGITYV LNASNTCPKP EFISESHFMR IPVNDNYCEK LLPWLDKTNE FIDKAKVSNS
RVIVHCLAGI SRSATIAIAY IMKTMGLSSD DAYRFVKDRR PSISPNFNFL GQLLEFEKGL
RLLKALSSGQ EKSEQPSEAA EPKGEAASRP KEARLEGETE ISSESEAKLP SPTSLQHGFN
GLNLSAERIL DTNRLKRSFS LDIKSVYMPG QCPRITPVHV EDVPKLCKLD SPSPRASNGI
CHLSPASDSP SPADSESSLR PRSRRKSKQN GGSAGSSPVH SFSFGLAQPP VHKSPSLDEN
LKSPMLLGLP TLGTGPMWTK HRDTAQATTP VTPTECEKFL SWLDKTNELI DKASNSRDPA
QATTPVTPTG DAPWFYESLS GGGGGGAGAV HFPGPLGCGA LPGPREAVRL RPKASEVREA
RASWHEDAPV AAGNSADKQF KRRSCQMEFE EGIQETRSRE ELGKIGKQSS FSGSMEIIEV
S
//
