ID A0A3B4DA42_PYGNA Unreviewed; 763 AA.
AC A0A3B4DA42;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Toll-like receptor 4 {ECO:0000256|ARBA:ARBA00040109};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000019961.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000019961.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR AlphaFoldDB; A0A3B4DA42; -.
DR STRING; 42514.ENSPNAP00000019961; -.
DR Ensembl; ENSPNAT00000030142.1; ENSPNAP00000019961.1; ENSPNAG00000005030.1.
DR GeneTree; ENSGT00940000156323; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF521; TOLL-LIKE RECEPTOR 4; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 4.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 616..759
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 763 AA; 87150 MW; DE7946DB0D34898D CRC64;
MLDFSFNFLP TLRRTVFPQL YNLKCLDLTR CHIHHITDDA FHNVKNVATL ILTGNPVSYI
GPDGLNSLRK LQRLVLVDTG LSSLNVQFNN LTGLQELNIG TNNIQSMALP PFMIKFRDFS
SLDLHANNIS ILRVDDTDVL RRMRGNITLI LSQNPILYIE PGTFQNLHLR ELNIRSAFVS
LNALRDGLKG LGGLNVDKFI IGNYREGNAG TPEGIYLDGL CMINFKEIEF LRLGSSASDF
HCIVNATKIK IERGAIRTIE NVPFQNIKEL FIGYNNVPMN LKLSHLHSLE KLVILENKYT
FFKGLSDMPK LQHVDLSGGK MSLVRCCSEY FRGMPNLRSL NLSVNTDLSL NKEPFSGLTS
LEVLDLHLTS LSGLTVQFEL FKNLPYLQFL DISYSDTTFR STMTFSYLNN LKVLKMAGIN
IQGDALTYLF QNLTFLELLD ISDCKIESIA WKTFKGLPRL KHLVLNQNRF MVLDFLTHPN
LKGLRVFEVH TNNIASIALN ILQNLPTNLS VFDLSFNPID CSCSQMNFIL WITGHQQIFP
KSNDILCKIS SQAPKMRVID FDVESCIHIR RLAIVLSICA VLLFVLASVL AYRFQFYLRY
GCVLLRGYRA SRQQECSYDA FVIYSNKDES WVMDELVENL ENGIPPIHLC LHVRDFEAGK
TITSNIIDEG IMGSRKIIVV ISKHFIESSW CRFEFEVAQS WLVTQGNANI IIIILEDVEE
EKTKKVFGLH KHLKKNTYLK WSGNPISNMR FWIRLRKAVM MRN
//
