ID   A0A3B4DA62_PYGNA        Unreviewed;      1022 AA.
AC   A0A3B4DA62;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Cytoskeleton-associated protein 5-like {ECO:0000313|Ensembl:ENSPNAP00000020338.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000020338.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000020338.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000256|ARBA:ARBA00004629}.
CC   -!- SIMILARITY: Belongs to the TOG/XMAP215 family.
CC       {ECO:0000256|ARBA:ARBA00025722}.
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DR   AlphaFoldDB; A0A3B4DA62; -.
DR   Ensembl; ENSPNAT00000030834.1; ENSPNAP00000020338.1; ENSPNAG00000027415.1.
DR   GeneTree; ENSGT00390000014757; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0061863; F:microtubule plus end polymerase; IEA:InterPro.
DR   GO; GO:0051010; F:microtubule plus-end binding; IEA:InterPro.
DR   GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:InterPro.
DR   GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR   GO; GO:0007051; P:spindle organization; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024395; CLASP_N_dom.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR034085; TOG.
DR   InterPro; IPR045110; XMAP215.
DR   InterPro; IPR048491; XMAP215_CLASP_TOG.
DR   PANTHER; PTHR12609:SF0; CYTOSKELETON-ASSOCIATED PROTEIN 5; 1.
DR   PANTHER; PTHR12609; MICROTUBULE ASSOCIATED PROTEIN XMAP215; 1.
DR   Pfam; PF12348; CLASP_N; 1.
DR   Pfam; PF21041; XMAP215_CLASP_TOG; 3.
DR   SMART; SM01349; TOG; 4.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
PE   3: Inferred from homology;
KW   Centromere {ECO:0000256|ARBA:ARBA00023328};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1..227
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   DOMAIN          267..504
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REPEAT          438..476
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          535..767
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   DOMAIN          797..1021
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REPEAT          966..1003
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REGION          498..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          762..793
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1022 AA;  112328 MW;  D281D0B932A28C4B CRC64;
     MGDDSEWMKL PTDQKCEHKV WKARLSGYTE ALQQFQRITD EKSPEWGKYQ GLVKKFVTDS
     NAVAQLKGLE AALAYIGSAH VASRTVGEVV SGVVCKVFNQ PKARAKELGS DICLMYVEIE
     KAEAVQEELL KGLDNKNPKI ALACVEVLRR AVSEFGSKII SLKPVVKVLP KLFESREKAI
     RDEAKMLAVE VYRWIRDALR PPLQNINSVL LKELEEEWAK LPSSAPRQTR FLRSQQDLRV
     KFEQQQQNEG EGGEDSEEAA PAVDAYELLE AVEILSKLPK DFYEKIEAKK WQERKEALEA
     LEALTKNLKL ESGEYGDVVK ALNKVIGKDT NVMLVTIAAK CVAGLATGLR KKFGTYAGHL
     VPTILEKFKE KKAQVVQALQ EAIDAVFLST TLQNVSEDVL AVMDNKNPSV KQQASLFLSR
     SFRHCTPTTL PKSLLKPFCV ALLKLVNDSA PEVRDAAFEA LGTAMKVVGE RAVNPFLADL
     DKLKVDKIKE CSGKVELAGG KKPAGQVKAP SKPEPPAEAP AKTSGPPKKT PAPAVAKPEV
     CEEKAAVVLP ASCMQMLDSA NWKERLAAME EFHKAVEQMD SKEMPCQALV RMLAKKPGWK
     ETNFQVMQLK LQVVSAVAQR GSFSRTSALA VLEAVLEKVG DVKCGVRAKE ALTGIAEACS
     LPWTAEQVVS LAFAQKNPKN QAEALSWLSN AIKEFGFAGI NVKAFINNVK AALAATNPAV
     RTAAISLLAA MYLYMGAPLR MFFEDEKAAL LSQIDAEFEK MKGQTPPAPI RGCSKASGGE
     EADAQEEEAE GGEDVVDLLP RTDISDKITS EMVSKIGDKN WKMRKEGLDE VAAALSEAKF
     IKPSIGELPV VLKARLADSN KILVQQTLSI LQQMATGMGP AIKQHVKGLG FPILTVLADS
     KNTVRAAALA TLNAWVEQTG MKEWLDGEEL SEELKKENPF LRQELLGWLA VKLPTLRSVP
     SDLLLCLPHL YSCLEDRNAD VRKKAQDALP MFMMHLGCDK MNKAAAKLKV RLDYLRRSLF
     QM
//