ID A0A3B4DBE8_PYGNA Unreviewed; 1275 AA.
AC A0A3B4DBE8;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Multiple epidermal growth factor-like domains protein 6 {ECO:0000313|Ensembl:ENSPNAP00000021742.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000021742.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000021742.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3B4DBE8; -.
DR STRING; 42514.ENSPNAP00000021742; -.
DR Ensembl; ENSPNAT00000033301.1; ENSPNAP00000021742.1; ENSPNAG00000004489.1.
DR GeneTree; ENSGT00940000156971; -.
DR OMA; SCPDGCC; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 6.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043:SF9; PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00053; Laminin_EGF; 5.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 24.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00180; EGF_Lam; 13.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 13.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 10..91
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 90..125
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 168..208
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 587..617
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 802..837
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1056..1091
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1142..1177
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1185..1220
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 115..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 607..616
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 827..836
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1081..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1167..1176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1210..1219
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1275 AA; 137608 MW; D639D8A855708167 CRC64;
HLNLASLALS PNCSTFTEVQ MLGTMQPCVQ AFTRMVKVWK QGCSPQRWCM GYERRTGYYT
AYRQVYSMEL QTVYKCCPGW TQRGEERGCL HRLCSDGTCF NGGRCSDTGD QVCECPAGFQ
GPRCQYDVNE CENSNGGCEG TCCNTIGSFY CRCPEGSTLG ADGKTCQDVD ECVELNGGCQ
QKCVNTLGSY YCECSAGFRM HADARTCIAV NSCLVKNGGC EHTCVDMGND HYKCECRRDY
QLKSDGRHCK LKDPCLEGNG GCAQLCSSEN KVIECSCRSG YTLATDRQSC DDVDECVTGQ
ARCAHGCVNM LGSFKCVCNP GFELGVDGKQ CYRIEMEIVN GCEKNNGGCS HHCEHTTSGP
VCSCNHGYQL AYDLRTCIDS DECEGEEACC HQYCKNYPGG YECSCKPGYT LSPDGCACDD
VNECVLETSG CNHYCVNMPG SYECFCREGF RLDYDQQTCL QEEEEEQEKE GGEEELEILR
LPDLLFRRAP QLLQYTAALH SPYDSEDTHT SYSEHTRNQE QREELTVISR IMCVTGSFGE
DCSVTCEDCA NGGACGEKRD GCVCTTGWTG FTCNQTCAEG TYGVGCNSLC ACQNGGQCDP
VNGKCNCPPG VHGLHCENGC AQGFFGRFCR RKCNCPDNGR CHHLYGGCFC APGLYGKFCH
LPCPRWTHGV GCSEECDCVQ DNTLSCGPQN GTCICKPGYH GDRCNTECAA GFYGSGCKER
CNCSHGASCN RTTGECQQKC PAGLYGEKCQ LVCEAGFWGP GCANQCQCVK SAVPCEARTG
RCFCEPGYTG EQCEQKCPEG QYGPDCEHVC DCMNGAGCNH VSGTCSCTSG WTGTHCEKKL
FYGMNCMQMQ AHQICIAIKL CFICIYVHLF MYVFVAVCPV GLYGQGCEQK CKCDHGTSCH
HATGQCVCEP GWTGLTCNKS CSPGWFGKNC SQVCECPVGM ACHHVTGRCG CPAGFMGSSC
EKTCIQGQYG LNCSHVCSCS GPHQLCHHVT GRCTCPPGYY GSHCQLKCRE GTYGPGCKKR
CRCANGGRCD FKTGACLCQP GYLGANCRTS CPAGHYGKDC AKTCSCGEGG LCHPVSGRCT
CTPGRTGQSC QQVCPRGRYG AQCRSLCTCV NGSVCDPADG TCRCGLGWTG TRCEEACVSG
RFGADCDQAC MCLNNGSCDR FTGSCSCTAG YYGPTCQHQC PAGFFGKLCS QPCECTQGHT
CDHVTGQCMC PPGYHGNHCQ KPGLHAPLSC VSGRYGPGCS LQCHCAHGGQ CDPRNGRCAC
PLTWLGPTCE EGMYS
//
