ID   A0A3B4DCN1_PYGNA        Unreviewed;      1272 AA.
AC   A0A3B4DCN1;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Ras/Rap GTPase-activating protein SynGAP-like {ECO:0000313|Ensembl:ENSPNAP00000021208.1};
GN   Name=SYNGAP1 {ECO:0000313|Ensembl:ENSPNAP00000021208.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000021208.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000021208.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4DCN1; -.
DR   Ensembl; ENSPNAT00000040423.1; ENSPNAP00000021208.1; ENSPNAG00000028272.1.
DR   GeneTree; ENSGT00940000158438; -.
DR   OMA; SHVFPRE; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd04013; C2_SynGAP_like; 1.
DR   CDD; cd13375; PH_SynGAP; 1.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   CDD; cd22265; UDM1_RNF168; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR021887; DAB2P_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037779; SynGAP_PH.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF25; RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF12004; DAB2P_C; 1.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1216..1237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1249..1269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          172..206
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          197..315
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          382..574
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          669..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          919..949
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          966..1068
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1112..1171
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1272 AA;  143827 MW;  4202868C1B19ECD3 CRC64;
     HPGWNPRMIS GNQLYMLDQE EVHPLLMRER RSESHRNKLL RRTVSVPVEG RHHPEMARLR
     RKSIATGRQP SMETPPIAPP QPFRHFLGRR LKGSIKRAKS QPKLDRTSSF RHMILPRFRS
     ADQDRTRLMQ SFKESHSHES LLSPSSAAEA LDLTLDEDAI IKPVHSSILG QEYCFEVTTA
     SGTKCFACRS AAERDKWIEN LQRAVKPNKD NSRRVDNVLK LWIIEARELP PKKRYYCELC
     LDDMLYARTT SKPRTDTVFW GEHFEFNNLP AVRNLRLHLY KETDKKRRKE KSTYLGLVSI
     PISSITGRQF VEQWYPVIQP SVLAKGGGVG GGKIINASLR LKSRFQTMSI LPIELYKEFA
     EYVTNNYRTL CAVLEPLLSV KSKEEVACAL VHILQSTGKA KDFLSDMAMC EVDRFIDREH
     LIFRENTLAT KAIEEYLKLI GHKYLKDALG DFIRALYESE ENCEVDPMRT PPSVLPDHQA
     NLRMCCELAL CKIVNSHCVF PRELKEVFAS WRVRCAERGR EDIADRLISG SLFLRFLCPA
     VMSPSLFNLT QEYPDEQTSR TLTLIAKVMQ NLANFSKFGS KEEYMGFMNE FLEMEWGSMQ
     QFLYEISNLD SVSNAGAFEG YIDLGRELSI LHSLLWEVMA QLSKDAIIKL GPLPRLLNDI
     SMALRNPHLQ RQPSHQTDRQ PPERQTDRLL SRPSFNRGIS SEFQNVMMRD LNSLDTSIYT
     TRGSIDITRL PSPTSAMSSG GVPPSRAGMG DVFYVTRPPL ARSSPAYCTS SSDITDPDPK
     VSLQGKYIWN EWVGERMNSV SNLQSVGDML NSSQASLAGL GSFGAGMSGG LRLSQLSQMG
     TTTDSLSQQQ QQQAAALRFP LSFQNPLFHM AADGPQLHHQ HSRAQPPAPH LLAPEPDPSH
     PAYLPQFARG GFSRSEDLST LRPGPHLGQP SIIHSHSYSD DYSRHNQGDY GRRQISMHMQ
     DNLQQQQMMG MASQTGTSHS SLASPPSTVQ PVRQSSMAPP PMQRMKSQTS HQLAVSSAAG
     ATPPSKTRPQ SGNLLQSPES GFGGRQQGPR QQLSGSSPNT LNPPTPASER TVAWVSNMPH
     LSADIESSRI DREEYKLKEY SKSMDESRLD RVREYEEEIH SLKERLMMSH RKLEEYERRL
     LTQEQQTNKI LLQYQSRLED SERRLRQQQL EKDSQIKGII DRLMAVEDEL RAGAVSEHKA
     RIFADQVCFP IHTLSLSLSL SLSIFLSPSP FLCMSVLSIK IISAVSNLVY RFYVSTSVTV
     GMSLCWFALL VG
//