ID A0A3B4DCT3_PYGNA Unreviewed; 1176 AA.
AC A0A3B4DCT3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=MAN2A2 {ECO:0000313|Ensembl:ENSPNAP00000022232.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000022232.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000022232.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR RefSeq; XP_017555591.1; XM_017700102.1.
DR AlphaFoldDB; A0A3B4DCT3; -.
DR STRING; 42514.ENSPNAP00000022232; -.
DR Ensembl; ENSPNAT00000034294.1; ENSPNAP00000022232.1; ENSPNAG00000029636.1.
DR GeneID; 108428807; -.
DR CTD; 4122; -.
DR GeneTree; ENSGT01030000234638; -.
DR OrthoDB; 5474711at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF57; ALPHA-MANNOSIDASE 2X; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 502..588
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1176 AA; 133400 MW; 8A4DFC864F596DA0 CRC64;
MKLKKQVTVC GGAIFCVAVF SLYLMLDRVQ HDPARRQNGG NFPRSQISVL QNRIEQLEQL
LEENHQIISH IKDSVLELTD TGAVSPSGQL PFRSANGSWV LPFDGRPTFL SVKPQDCQFA
LGRRGQTDLQ MLDVYSLLSF DNVDGGVWKQ GFEITYEPTE WDNEPLQVFV VPHSHNDPGW
VKTFDKYYND QTQHILNNMV VKLAEDPRRK FIWSEISFFV KWWESADAHK QDVMRKLILG
GQLEIVTGGW VMTDEANAHY FAMIDQLIEG HQWLEKNLGV TPRSGWAVDP FGHSATMPYL
LKRANLTSML IQRVHYSVKK HFSSSRSLEF MWRQAWDPES GTDLFCHMMP FYSYDVPHTC
GPDPKICCQF DFKRLPGSRV NCPWKVPPRA ISDANVAERA NVLLDQYRKK SKLFRSKVVL
VPLGDDFRYD KALEWDQQYV NYQKLFDYMN SHPEMHVQAQ FATLTDYFSA VYKANGVAQG
QRPPGYPVLS GDFFAYADRE DHYWSGYYTS RPFYKNLDRV LESHLRGAEI LYSLAVAHAR
HAGMEGRYPT SDYSLLTDAR RNIGLFQHHD AIAGTAKEAV VIDYGTRLLR SLIGLKRVII
NAAHFLIMKN KDVYRFYQTE PFLETDDRRA THDSLPQQTL IELDSSPRYL VLFNPVEQER
LCVVTVLVNS ARVRVLTEDG QTLPVQLSAQ WSSAVQMSGE VYQASFMARL PALGLAVFHL
YDSVDSPMTL RSDTLLRLPG RSQSVRGIDP LPVRSQVADP QPFYIQSQSL TLGFSGTTGL
LESIRRKDDP QEVRVQIQFF TYGTRPSKDK SGAYLFLPDG NAKPYTQRDP PIVRVVEGPL
FAEVVTYYQH FQQTIRIHNV PGVDGLSLDI TTMVDIRDQT NKELAMRLLT DIQSEDTFYT
DLNGFQIQPR RYLQKLPLQA NFYPMPTMAY IQDSQYRLTL HTGQALGVSS LASGQLEVIL
DRRLMQDDNR GLGQGLKDNK RTANRFRLLL ERRSSSSRPV GSYAKVSHML NKIIAHVFGE
SKKEAVDSGP VSFPSLLSHM TSAILNHEVL ALPVIPKKRG VPPLRTFSPL AAALPCDFHL
LNLRSIQNQD AHSPSPYTAL LLHRLGLDCG LEAQNPGFNC STTQGKLAVS ALFRGLDLQL
LQPMSLTLMY SAAPLSNSSI ISLEPMELSA FKLKLR
//
