ID   A0A3B4DD03_PYGNA        Unreviewed;       791 AA.
AC   A0A3B4DD03;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Epidermal growth factor receptor pathway substrate 8 {ECO:0000313|Ensembl:ENSPNAP00000021333.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000021333.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000021333.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the EPS8 family.
CC       {ECO:0000256|ARBA:ARBA00006197}.
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DR   AlphaFoldDB; A0A3B4DD03; -.
DR   Ensembl; ENSPNAT00000040540.1; ENSPNAP00000021333.1; ENSPNAG00000004351.1.
DR   GeneTree; ENSGT00940000156403; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   CDD; cd01210; PTB_EPS8; 1.
DR   CDD; cd09540; SAM_EPS8-like; 1.
DR   CDD; cd11764; SH3_Eps8; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR039801; EPS8-like.
DR   InterPro; IPR033928; EPS8_PTB.
DR   InterPro; IPR035462; Eps8_SH3.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR013625; PTB.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR041418; SAM_3.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12287:SF21; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8; 1.
DR   PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR   Pfam; PF08416; PTB; 1.
DR   Pfam; PF18016; SAM_3; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          504..563
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          17..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          609..692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        611..641
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..668
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..692
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   791 AA;  87980 MW;  64741823CF16396C CRC64;
     MNGYAAPTYP SGGFSSYSSQ LNGHGSPSPE LPAHNANKSS GKALYGTDGL YFLRSSAKHK
     KKEQRKSYTK NSINSMTDTS QYHVEHLTTF VMDRKDAMMT IEDGIRKLRL LDAKGKVWTQ
     DMLLQVDEKA VSLIDPDTKN ELENFPLATV QHCQAIMNSC NYDSILALVC KESGQGKPDL
     HLFQCDDIKA NLIHADIDSA ISDHKGGKAK KRPETLKMIL KSDGAIPPPP GGPAPEPPAT
     VNQVDVKSRV AAWSAWANEQ QDYDKQRPYG EQDESPEMTA ARVDRDVQIL NHILDDIEYF
     VTKLQKAAEA FNELSKRKKS KKNKKKGPGE GMLTLRAKPP GQEEFVDCFQ KFKHAFNLLG
     KLKNHIQNPS AVDLVHFLFT PLRMVIHTSG GIDLAKSVLV PLLTREAIDF LHSAGTPEER
     HLWVTLGDGW TKCRLEWPKD HYFPPHTLRF RDGWEPPVLV SREQDLTQLA ETLAQAEIHR
     QEEQASVQDF PSGDGSFDAH ARGQPRNFAK SKYDFVARNN TELSVVKDEV VEVLDDRKQW
     WKVQNGVGAT GYVPNNILEI SRAVDVTGRG EPIYSHTIQL MMPKKEFELF KQLLGELNEK
     QRTDYVPKPV ATAIPPAPTP PPPAPALVQL PTPPLPPAAV PPAAELQRSS PSNVSRQNSS
     NSSDNGSVTM RDHQKERAAP TNRRKSNMEE VQDELMHRLT LGRSAQKKFQ APARSTSLPA
     VNITYDSNPE EVKAWLQAKG FSAVTVNSLG VLTGAQLFSL NKDELKTVCP DDGARVYSQV
     TVQKAALEVF F
//