ID A0A3B4DE10_PYGNA Unreviewed; 497 AA.
AC A0A3B4DE10;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 2-like {ECO:0000313|Ensembl:ENSPNAP00000021688.1};
GN Name=ENTPD2 {ECO:0000313|Ensembl:ENSPNAP00000021688.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000021688.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000021688.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR RefSeq; XP_017566815.1; XM_017711326.1.
DR AlphaFoldDB; A0A3B4DE10; -.
DR STRING; 42514.ENSPNAP00000021688; -.
DR Ensembl; ENSPNAT00000033209.1; ENSPNAP00000021688.1; ENSPNAG00000028812.1.
DR GeneID; 108435468; -.
DR GeneTree; ENSGT01100000263542; -.
DR OMA; NEECRYQ; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF33; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..497
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017318423"
FT TRANSMEM 343..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 165
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 204..208
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 497 AA; 55739 MW; FCF8EBFEDE11B6E0 CRC64;
MDSKWFKMLM PLMLLVFAVV TLLLLTLPVE EMKEPPKYMY GIVLDAGSSH TAMYIYKWPA
DKQNGTGVVT QHSECSVKGG GISSYAGQKG AAGRSLEACL KQAVQDIPQT RHHLTPVYLG
ATAGMRLLNI SSPEMSTQVL QEVEDTIKSF PFCFRGATIL SGQQEGVYGW VTVNYLLENF
IKYSFVGHWM KPGRQTVGAL DLGGASTQIT FVTPEKVEDE NNSMTLRLYG QDYSLYTHSY
LCYGKGEFLR RLLAHLITSQ GPTGTVYNPC YPSDHNETLE LQQVFESPCT KSQRPAPYEP
HASVTIQGTG DYHLCVGNIS EIFSWQDCPF SQCSFDHVFQ PNITGSFMAF SVFFFTYSFL
QKCVGISIST PELLQQAART VCNMTTEEMF KRDEEDRSYL KEYCAVTVYI QVLMLRGYHF
DEHSLSRVAF QKKAGDASVG WALGYMLSLS NQLPGESVVM RKGMHTAVWI VLLILQICLM
VITLIFMALS CWKKVFA
//
