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Database: UniProt
Entry: A0A3B4DGS0_PYGNA
LinkDB: A0A3B4DGS0_PYGNA
Original site: A0A3B4DGS0_PYGNA 
ID   A0A3B4DGS0_PYGNA        Unreviewed;       394 AA.
AC   A0A3B4DGS0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Splicing factor 45 {ECO:0000256|PIRNR:PIRNR031066};
DE   AltName: Full=RNA-binding motif protein 17 {ECO:0000256|PIRNR:PIRNR031066};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000022638.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000022638.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Splice factor that binds to the single-stranded 3'AG at the
CC       exon/intron border and promotes its utilization in the second catalytic
CC       step. Involved in the regulation of alternative splicing and the
CC       utilization of cryptic splice sites. {ECO:0000256|PIRNR:PIRNR031066}.
CC   -!- SUBUNIT: Associates with the spliceosome.
CC       {ECO:0000256|PIRNR:PIRNR031066}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR031066}.
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DR   AlphaFoldDB; A0A3B4DGS0; -.
DR   Ensembl; ENSPNAT00000034872.1; ENSPNAP00000022638.1; ENSPNAG00000030046.1.
DR   GeneTree; ENSGT00790000123099; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR   CDD; cd12647; RRM_UHM_SPF45; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR040052; RBM17.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR003954; RRM_dom_euk.
DR   InterPro; IPR034653; SPF45_RRM.
DR   PANTHER; PTHR13288:SF8; SPLICING FACTOR 45; 1.
DR   PANTHER; PTHR13288; SPLICING FACTOR 45 SPF45; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PIRSF; PIRSF031066; Splicing_factor_SPF45; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00361; RRM_1; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   4: Predicted;
KW   mRNA processing {ECO:0000256|PIRNR:PIRNR031066};
KW   mRNA splicing {ECO:0000256|PIRNR:PIRNR031066};
KW   Nucleus {ECO:0000256|PIRNR:PIRNR031066};
KW   RNA-binding {ECO:0000256|PIRNR:PIRNR031066, ECO:0000256|PROSITE-
KW   ProRule:PRU00176}; Spliceosome {ECO:0000256|PIRNR:PIRNR031066}.
FT   DOMAIN          228..268
FT                   /note="G-patch"
FT                   /evidence="ECO:0000259|PROSITE:PS50174"
FT   DOMAIN          298..382
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          61..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          189..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..146
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   394 AA;  44248 MW;  883A9EEA527F0C27 CRC64;
     MSLYDDLGVA TSDAKTEGWS KNFKLLQSQL KVKKAALTQA KTQRMRQSTV LAPVIDLKRG
     SAGDDRQISD TPPHVAAGLK DSAPAGFSAG DVLIPLADEY DPMFPNDYEK VVKRHREEQQ
     RQREQERQKE IEEREKKRKE RHEGGAPSGF SRFPTEADSD EDEEYEKEKR KRITLWLYLS
     SVGMAASYSY DEEGRQRSKA AIPPPIYEDS ERPRSPPGPT SSFLANMGGT VAHKIMQKYG
     FREGQGLGKH EQGLSTALSV EKTSKRGGKI IIGDSTEKNT SKKNEVNPLT EILKCPTKVV
     LLRNMVGRGE VDEDLEAETK EECEKYGKVV KCVIFEISDV ADDEAVRIFL EFERVESAIK
     AVVDLNGRYF GGRVVKACFY NLDKFRVLDL GEQV
//
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