ID A0A3B4DIG9_PYGNA Unreviewed; 340 AA.
AC A0A3B4DIG9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Caspase-8-like {ECO:0000313|Ensembl:ENSPNAP00000024192.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000024192.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000024192.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR RefSeq; XP_017580050.1; XM_017724561.1.
DR RefSeq; XP_017580051.1; XM_017724562.1.
DR STRING; 42514.ENSPNAP00000024206; -.
DR Ensembl; ENSPNAT00000010729.1; ENSPNAP00000024206.1; ENSPNAG00000001157.1.
DR Ensembl; ENSPNAT00000010743.1; ENSPNAP00000024192.1; ENSPNAG00000001157.1.
DR GeneID; 108443729; -.
DR GeneTree; ENSGT00940000164225; -.
DR OMA; PCFRRET; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 3.30.70.1470; Caspase-like; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF5; CASPASE 10; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PIRSF; PIRSF038001; Caspase_ICE; 3.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
FT DOMAIN 1..90
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 117..235
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 247..282
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 340 AA; 38728 MW; 18D03A46647557DF CRC64;
MEIVRQHKTT LIRILSGDAK FVLQHVHQAK LITGHEYDNL KDDISHHSRQ DFAINLLDKM
IHKGDKQCHK FLELLEHDEM QETFPLLNDL LIPPALRQGV PKINEYKINE YKMSSDPRGA
CVIINNMHFD KSSGLSPRRG SEVDVACLDE VFKWLAFTVE LHTDKTAVEM KEILKELSRR
EHSGDCFVCC ILSHDSEGGF FGTDGQVVRP SDILQPFARA NCPSLADKPK VFILHTGWEQ
PEYAIPDSDF LLALATIPGL HSYRNTSRGS WFIQSLYKML KEGCKRGEDI LTILSQVIVE
VSTFETNRTA PPSVFGLSFR QIPHIDLTLR RRLVFHAPAD
//
