ID A0A3B4DIZ9_PYGNA Unreviewed; 2446 AA.
AC A0A3B4DIZ9;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=GCN1 activator of EIF2AK4 {ECO:0000313|Ensembl:ENSPNAP00000023101.1};
GN Name=GCN1 {ECO:0000313|Ensembl:ENSPNAP00000023101.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000023101.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000023101.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
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DR STRING; 42514.ENSPNAP00000023101; -.
DR Ensembl; ENSPNAT00000013478.1; ENSPNAP00000023101.1; ENSPNAG00000007654.1.
DR GeneTree; ENSGT00940000153612; -.
DR OMA; EREIWSV; -.
DR Proteomes; UP000261440; Unplaced.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 6.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR Pfam; PF02985; HEAT; 2.
DR SMART; SM00567; EZ_HEAT; 3.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 4.
DR PROSITE; PS50077; HEAT_REPEAT; 4.
PE 3: Inferred from homology;
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1147..1383
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1401..1439
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1443..1481
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1563..1599
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1791..1828
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 2446 AA; 267641 MW; C8BCECFB1CB1239E CRC64;
MTTLLSLDQS PSSLPLLALC VDYCTAQKDM ATINKHKAAL LDLYMKTVLM SKARPLIFAF
FPENSMQTIS SMLASLTLDL SQYAKDIVKG LASQLKASNT ELMEQAVQAL RNLSQQCSDP
NAVQDLITHL FGILGGSEGK LTAVAQKMNV LSGIRSCSHH AVSGSSSQSL SASVAVLFIP
FLQQEVHEGT LVHAVSVLSQ WTGRLNTEVP AALRDWFKKA FTLKTSTSPV RHAYLQAMLT
AFRGDTLSQA LDFVPLLIQT VEKAAAQSSQ HTLLTEGVAA SVLLCRLSML DSLPEAKLTS
FWNLILDEKK PLLTTEKFLS QASEEALCAV LQLCERLFLD HPHRLNNSKS QMYHRATVAV
LLCRVWRVRK RGQQSVKKLL SSLGGSSLAH GLLGELRVVI NKHKVLPPEA LQTETGELTD
LGRSYVPPRN FLEALSAICS VAGQWNDPAE AEKLALDIII VTHHPSIVAA KSQLWPFLLS
GMKIDASEFI DTHMESILPL LLEANTDNQA VRNAVGELSV LSPRKLLPRV MDHVTQWLSN
PALKQVTHHE YAIMHTPEGE LHDKSIILSA QQESTKKGNM KRENKAYSFK EQIIELELQE
EIKKKKGIKD EVQLTSKQKE MMQNQLEKES AIRKRLQGLD MELQCAVGLL EATIACHPPQ
ISWHLPGVLQ ALLPLLHSPL AAPLVQKAYI HTGTCLLPKE LHNLALLVGH VTLRLLKPEC
DLDPAWAQED LNTATHRTVH LLHTYTVLQK ESKPDVHPLS APAFSFCFPL LQAVLSQNSG
ASEEAELMLT RALQTMHTHA QLRSETDCAD TFIDENGPEL LPRVNMLLLL TKVIGTATPR
LQVLASSCLT SLCTSAGGQE GCALAEQAEI DVLLDALLAP CFSVRDAALR GLLELELALP
TDSSEPGGLS VLRRLWVAKF DVEEEGRALA EKLWQTLCLE LVPELCPLLI GDVTHHEETV
RAAGAEALSV AVSQYQEQSA AVLSQLTELY QQKLYRPPPV LDALGRVISE APPDQWEARC
GIALALNKLS QCLDESQVTP LFLFFVPDAL NDRHSEVRRC MLDAALAVLN THGKDNVNSL
LPVFEEFLKN APQDASYDSV RQSVVILMGS LAKHLDKSDP KVKPIMAKLI TALSTPSQQV
QESVASCLPP LVPAIKEDAG DMVRKLLQLL LESDKYAERK GAAYGLAGLV KGLGILSLKQ
QDIMTTLTDA IQDKKNSRRR EGALFAFEML CNMLGKLFEP YVVHVLPHLL LCFGDGNQYV
REAADDCAKA VMRNLSAHGV KLVLPSLLVA LEEESWRTKA GSVELLGAMA YCAPKQLSSC
LPSIVPKLTE VLTDSHVKVQ KAGQQALRQI GSVIRNPEIL AITPILLDAL TDPSHKTQHC
LQTLLETKFV HFIDAPSLAL IMPVVQRAFQ DRSTDTRKMA AQIIGNMYSL TDQKDLSPYL
PSVIPGLKTS LLDPVPEVRT VSAKALGAMV KGMGESCFDD LLPWLMETLA SEQSSVDRSG
AAQGLAEVMA GLGVEKLDKL MPDVVQTASK VDIASHVRDG YIMMFIYLPL TFGERFTPYV
GPIIPCILKA LADENEYVRD TALRAGQRII SMYAETAIAL LLPELEQGLF DDLWRIRFSS
VQLLGDLLFH ISGVSGKMTT ETASEDDNFG TAQSNKAIIG ALGVERRNRV LSGLYMGRSD
TQLVVRQASL HVWKIVVSNT PRTLREILPT LFSLLLGFLA STCPDKRTIA ARTLGDLVRK
LGEKILPEII PILEEGLRSE KSDERQGVCI GLSEIMKSTS KDAVLVFSES LVPTVRKALC
DPLEEVREAA AKTFEQLHAT IGHQALDDIL PALLKQLEDE ETAEFALDGL KQVMAVKSRS
VLPYLVPKLT APPVNTRVLA FLSSVTGDAL TRHLGVILPA LLSSLKDKLG TDEGSCQTVI
LSVEDEVGQR IIIEDLLEAT RGPDAGLREA SVTILNAYFS RTRLDYSAHT RTLLSGLMRL
LNDPNPEVLN QSWDTINSIT KKLDAGSQLA LIDDLHRDIR SAAAEVKGEH LPGFCLPKKG
VTCILPVLRE GVLTGSPEQK EEAARALGGV IKLTSAEALR PSVIHITGPL IRILGDRFAW
TVKTALLETL TLLLAKVGIA LKPFLPQLQT TFLKALQDSS RAVRLRAAEA LGQLVSIHTK
VDPLFAEQLS AIRNAEDSGV RETMLQALRF VVQGAGAKVD PTIRKNIITT LLGMLGHDED
ATRMASAGCV GVLCAFLSEE ELKTVLQQHV LADVSGVDWM VRHGRSLALA IAVKSAPEKL
CAPEYSSAVL EAVLSSATAD RIPIACSGIR AMGYLMKHQI RSAGGEAVSP RCLQNQSSDI
RLVTERVLWW IWKEADTPAM EPNLVKPVIK ALLDNTKDKN TSVRSQSEHT IVSLLRLRQG
EEGMQSVSAI LDSASNELLS ECFRRSLKKI SGLPDSNEEI DDTILT
//