ID A0A3B4DJ23_PYGNA Unreviewed; 1059 AA.
AC A0A3B4DJ23;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=VWFD domain-containing protein {ECO:0000259|PROSITE:PS51233};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000023126.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000023126.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3B4DJ23; -.
DR Ensembl; ENSPNAT00000013406.1; ENSPNAP00000023126.1; ENSPNAG00000007682.1.
DR GeneTree; ENSGT00940000162219; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR CDD; cd19941; TIL; 3.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR008037; Pacifastin_dom.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF371; MUCIN-5B; 1.
DR Pfam; PF08742; C8; 2.
DR Pfam; PF05375; Pacifastin_I; 1.
DR Pfam; PF01826; TIL; 3.
DR Pfam; PF00094; VWD; 3.
DR SMART; SM00832; C8; 2.
DR SMART; SM00214; VWC; 2.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 3.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 3.
DR PROSITE; PS51233; VWFD; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1059
FT /note="VWFD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017341276"
FT TRANSMEM 1024..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..216
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 387..544
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 814..981
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
SQ SEQUENCE 1059 AA; 116937 MW; D89E666E8091588C CRC64;
YSLAPMVTLT MLRVWVLSVA ALLNGLSAQE TECVTVSSGI NVNHNMQVCS TWGNFHFSTF
DGQFFQLPYT CNYILTTLCD STKTDFNIQM RRQYINNLPT IRSFTIKIDG VVVKLLDVPG
FHYNTEKSSE CCTLVIGYGA IHFCIVCKLY ESSVCCITPA QVEIPTKYRN QTCGLCGDFN
GVKDNEFIEN EYGHKWKMDA PAETCEEIEL HTKKCQSQNY LCEQLLSDPA FSNCHRLLSI
EAFVEACVRD VCQCNSSQAL CLCDTISEFS RQCAHAGGKP QNWRTNYLCG KECPFNLEHK
ECGSPCKDTC SNQEGSLVCN EHCSDGCFCP AGTVFNDIEE NGCIPVNKCP CIHNGRIYQP
GESYNRTCQK CVCSEGRWSC VNLDCPGTCS IQGGSHITTY DGKAYNFHGN CYYVLSKDSI
NDVTVLGHLV QCGQTEAETC LTDVKFIISE TSVSISKPMF YQVTVFKPST FYIIARSPGL
LLVIQMVPVM QVYIMASSKK KGTLSGLCGN FNDVQADDFK TKLGLTEGTG ATFANTWKAM
SNCPDISISQ ENPCSMKKYA REWCNMLTDP KGVFSPCHAE VNPKDYKDRC IYDTCNCAKS
EECMCAAVSS YVYACAAKRV QLHGWRNATC DCPGNMEYHY SLSGCGTTCR SLSGHDHTCQ
VIHTPVDGCG CAKGTYLSDK GECVPASSCP CYYNNQVVAP SQVIILFLFS LLACEAPMYF
FNCSNAGPEA RGTECQKSCQ TLDSDQCVST ECMSGCVCPS GLLADGQGGC VKENNCPCVH
NGVFYQPGQT VKEDCNTCTC RNGTWSCTHE DCPGTCTIYG DGHYITFDGR RYSFSGDCEY
TLVQDYCSNT LNGSFRVITE NIPCGTTGTT CSKSIKIFLG VRLSHKENIK VLIYDNSTEI
PYKSYTVGIY LVIEASHGLV LFWDKKTSLM IKLEPWFKGT VCGLCGNYDG NGKNDFVTRG
GEEVVEPLEL GNSWRVSPTC PKASSVSSPC DMRPHRQTWA VKHCSIIKSD VFSACHSLVS
SFNVNINLLI FIHVLYIVYM YYIHSPAGTA VQLLVNTNS
//
