ID A0A3B4DJP1_PYGNA Unreviewed; 470 AA.
AC A0A3B4DJP1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Phosphatidylcholine:ceramide cholinephosphotransferase 1 {ECO:0000256|ARBA:ARBA00039805};
DE EC=2.7.8.27 {ECO:0000256|ARBA:ARBA00038996};
DE AltName: Full=Sphingomyelin synthase 1 {ECO:0000256|ARBA:ARBA00042067};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000023154.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000023154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR STRING; 42514.ENSPNAP00000000727; -.
DR Ensembl; ENSPNAT00000013362.1; ENSPNAP00000000727.1; ENSPNAG00000007691.1.
DR Ensembl; ENSPNAT00000013368.1; ENSPNAP00000023154.1; ENSPNAG00000007691.1.
DR GeneTree; ENSGT00940000158306; -.
DR OMA; VACIYAM; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01610; PAP2_like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF28; PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..72
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 470 AA; 54173 MW; E6D59A7CFBA971F4 CRC64;
MGMKKAAQWS EEEVGLWLAE EGMQEYAGPL RNMDGRTLLQ LSQADFQKPP LSRITSDGGK
HLLEKIKTLN IEHHIEVHKN GFANGHVVVS HNGDARASSK NKQNGLVNGY NKELVRIPIP
EPTGLRFPPE WGKTGVAFLY AICCFVITTI MISIVHERVP PKEATPPLPD KFFDFFDRVE
WAFSVCEING MILVILWIIQ WSLMKHKSIV GRRFLFIVGT LYLYRCITMY ITTLPVPGMH
FKCSPKLYGD WESQMRRVMK MIAGGGLTIT GSHNMCGDYL YSGHTVMLTL TYLFMREYSP
RRFWWYHWGC GALCVVGVFC ILLAHDHYTI DVVVAYFITT RLFWWYHSMA NQPDLKGASQ
GNFLSRVWWY RFFQYLEQNV QTVVPRSYQI PFSWRSLQWG LCLWVCLNSR LFSGRGLQCP
VNVGRGFVLL CCPVCLGLHK SITFELFCNL SNGKKQKLLN FNSLSFFFDK
//
