ID   A0A3B4DJW3_PYGNA        Unreviewed;      1024 AA.
AC   A0A3B4DJW3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO3 {ECO:0000313|Ensembl:ENSPNAP00000023224.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000023224.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000023224.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   RefSeq; XP_017578345.1; XM_017722856.1.
DR   AlphaFoldDB; A0A3B4DJW3; -.
DR   Ensembl; ENSPNAT00000013165.1; ENSPNAP00000023224.1; ENSPNAG00000000451.1.
DR   GeneTree; ENSGT00940000156257; -.
DR   OrthoDB; 534027at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF16; ANOCTAMIN-3; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        429..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        506..524
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        581..605
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        625..648
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        676..699
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        799..821
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        849..873
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        949..974
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          161..415
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          418..992
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
FT   REGION          136..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1024 AA;  119787 MW;  B05C67342931A3DC CRC64;
     MYAAWFVRVR IFSNLGSQPN ATMVHHSGSI QSFKQQKGMH TSISEILKEK TLKPSRRSLP
     CLAQSQTHPH NLNHFLSVPL SPEPKANTNT HSVSASCTHI TTPPKDATKD QYVEEMETGA
     YESRTDESLL IQQKPVSRGK LEARTDSVRG NNAPTPSGLT FRDGKKRIDY ILVYKKSSPQ
     VEKRCTFERN LRAEGLMLEK EPSLTNNDIM FVKIHAPWDT LCKYAEQMNI RMPFRKKCYF
     SDWKKKTMGS RFHLRCRQVK SWLPRNPMKL DKEALPDLEE TDCYTAPFSR ARMHHFTINN
     RDSFFSNSTR SRIVHHVLQR TKYEDGKSKM APPLCCLSLL NYYGQHERLL IGQSGSTWEG
     INRLLGNGTY EAAFPPHEGS YKSRHPIKTH GPQNHRHLLY ERWARWGIWY KYQPLDLIRR
     YFGEKIGLYF AWLGWYTGML IPAALVGLFV FLYGLFTMDS SQVSKEICEA NTTIMCPMCE
     VNCSAWILSD SCVYAKVTHL FDNGGTVFFA IFMAIWATVF LEFWKRRRAE LTYDWDLIDW
     EEEEEELRPQ FEAKYSRKER VNPISGKPEP FQPFTDKLSR LMVSVSGIFF MISLVLTAVF
     AVVVFRLIAM EKFASFQWEF VKKNWQFATS GTGVCINFMI IMSLNVVYEK VAYLLTNLEH
     PRTESEWENS FALKMFLFQF VNLNSSTFYI AFFLGRFAGR PGDYNKLFNR WRMEECHPSG
     CLIDLCLQMG VIMVLKQIWN NFMELGYPLL QNWWSRRKMR RAGEQNNVEG KEQLPQWDKD
     WNLQPMNAHG LVDEYLEMVL QFGFTTIFVA AFPLAPLLAL LNNIIEIRLD AYKFVTQWRR
     PMPARATDIG IWHGILEGIG VVAVITNAFV IAITSDYIPR FVYAFKYGPC VDKGYRHEQC
     LKGYMNSSLS VFDMGEPKNG SQYQTRYCRY RDYREPPWSS EPYEFTLQFW HVLAARLAFI
     IVFEHLVFGI KTFIAHLIPD MPKDLCERMR REKYLMQEMM YEAELEHLQK ERKKNGKRYH
     HEWP
//