ID A0A3B4DK00_PYGNA Unreviewed; 576 AA.
AC A0A3B4DK00;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Pygopus homolog 2-like {ECO:0000313|Ensembl:ENSPNAP00000024707.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000024707.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000024707.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in signal transduction through the Wnt pathway.
CC {ECO:0000256|ARBA:ARBA00037400}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_017564027.1; XM_017708538.1.
DR AlphaFoldDB; A0A3B4DK00; -.
DR STRING; 42514.ENSPNAP00000024707; -.
DR Ensembl; ENSPNAT00000009502.1; ENSPNAP00000024707.1; ENSPNAG00000009346.1.
DR GeneID; 108433763; -.
DR CTD; 90780; -.
DR GeneTree; ENSGT00530000063948; -.
DR OMA; GGMVFPC; -.
DR OrthoDB; 5403712at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd15636; PHD_PYGO2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23194; PYGOPUS; 1.
DR PANTHER; PTHR23194:SF7; PYGOPUS HOMOLOG 2; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 497..555
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..137
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..177
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..235
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..285
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..343
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..417
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 576 AA; 56730 MW; 751605D05A300C1F CRC64;
MAAESGRLLA GQGQGKRGKG SQMKSPEKKK RKSSTQGATF SHLSEFAPPP TPMVDHLVAS
NPFDDDFSSS SRPGGAGVPG SAPFLPSPGA GGGGGGYGAP GRMAGGMGFM GGPGGPGGGQ
PGRRPPFVPP PPNAGPHHPL GFGGMPGFGG GGGGGGGFPP GGPSQFNMPP NFSPPMHPGQ
GFNPMLSPGA MGGGPGGGGP PHPRFGMQQP QHGQGGHPFN SPPLPGGPGP RGPPHGPMNS
MGGMPTGINM MGSMGGGMGP GNMVGGHPGL PPQGQFPPSQ DGPYPGPGTP GSEEGKNFVG
GPGGGPPGPP QQPPNLNPSG PPSNNATPGP SPASGPPQPG GGFPGHPDVQ QSTPNTPGQS
SSAPPPPNPN SSPTGPLNGP QPQQLPPNQH PPPNSAGGPA PNTPSSQQQP TPPNSTPGSA
PYNQQNSASG GGSMPNQPSN SNQNNLNNSG GNTPGSNPNP PSNSTSTPNT QSPLPTGQAP
PSAGPGSGPP KLGGGMVFPC GFCLSEVHDD QEAILCEASC QRWYHRDCTG LTEPAYGLLT
RESAAVWACD MCLKTKEIQA VYVRQSLGQL VAANEG
//
