ID   A0A3B4DK42_PYGNA        Unreviewed;       529 AA.
AC   A0A3B4DK42;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Mucolipin 3 {ECO:0000313|Ensembl:ENSPNAP00000023833.1};
GN   Name=MCOLN3 {ECO:0000313|Ensembl:ENSPNAP00000023833.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000023833.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000023833.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3B4DK42; -.
DR   Ensembl; ENSPNAT00000011653.1; ENSPNAP00000023833.1; ENSPNAG00000008347.1.
DR   GeneTree; ENSGT00950000183036; -.
DR   OMA; WQARRKF; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR049134; MCLN_ECD.
DR   InterPro; IPR039031; Mucolipin.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   PANTHER; PTHR12127; MUCOLIPIN; 1.
DR   PANTHER; PTHR12127:SF5; MUCOLIPIN-3; 1.
DR   Pfam; PF21381; MCLN_ECD; 2.
DR   Pfam; PF08016; PKD_channel; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          86..182
FT                   /note="Mucolipin extracytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF21381"
FT   DOMAIN          189..248
FT                   /note="Mucolipin extracytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF21381"
FT   DOMAIN          347..484
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
SQ   SEQUENCE   529 AA;  61292 MW;  79BDFEB822B2965C CRC64;
     MDDPDAPYLA FNDLNSNGGS MWSDILARQE QREVESFRRK LKYFFMNPCE KYRARGRKPW
     KLMLQIIKIA VITIQLVSFG LSNQMVVTFK EENLMAFKHL FLKDYTHHSS NSYAVYTQAE
     VYSHLSYIVD RFLRLRNITV GNHAYEKDGH YFTPLLMCQQ FYHNGSILPG NETFEIDAQV
     EEGRGLCRQR LLEVNVYFTL KAINLQTVQH HELPDCYDFS ITIRFNNRAH SGQIKVDLDN
     DVDINECRDW KVTGASPKNI YYTVLFDVVI ILTCLASLVL CTRSVSTGVQ LQFVTFFLRH
     FGKLVSWSDR MEFINGWYIL IVISDILTIT GSVLKIAIQL KALTSYDICS ILLGTGTMLV
     WIGVLRYMGY FKKYNILIIT LRAAFPNVIR FCCCAAMIYL GYCFCGWIVL GPYHDKFRSL
     NTVTECLFSL INGDDMFATF KNMQQKSYLV WLFSRVYLYT FVSLFIYMVL SLFITLITDT
     YETIKQQQSD GEPVSELQAF ISECKDHPSS GCYRVEGRSS TCLFCCVRR
//