ID   A0A3B4DKS6_PYGNA        Unreviewed;       404 AA.
AC   A0A3B4DKS6;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=C-terminal-binding protein 2-like {ECO:0000313|Ensembl:ENSPNAP00000023529.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000023529.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000023529.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR   AlphaFoldDB; A0A3B4DKS6; -.
DR   Ensembl; ENSPNAT00000012387.1; ENSPNAP00000023529.1; ENSPNAG00000000660.1.
DR   GeneTree; ENSGT00940000171352; -.
DR   OMA; RRNTWLC; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR   CDD; cd05299; CtBP_dh; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR043322; CtBP.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR46029; C-TERMINAL-BINDING PROTEIN; 1.
DR   PANTHER; PTHR46029:SF3; C-TERMINAL-BINDING PROTEIN 2; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003719}.
FT   DOMAIN          44..358
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00389"
FT   DOMAIN          140..323
FT                   /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02826"
SQ   SEQUENCE   404 AA;  44836 MW;  78A9613D501D5CB7 CRC64;
     MALLDKHKVK RQRLDRICEG IRPQIMNGPM HPRPLVALLD GRDCTVEMPI LKDLATVAFC
     DAQSTQEIHE KVLNEAVGAM MYHTITLTRE DLEKFKALRI IIRIGSGYDN IDIKAAGEMG
     IAVCNIPSAA VEETADSTLC HILNLYRRNT WLYQALREGS RVQSVEQIRE LASGAARIRG
     ETLGLIGFGR SGQAVAVRAK AFGFNVIFYD PYLQDGLERS LGVQRVYTLQ DLLYQSDCVS
     LHCNLNEHNH HLINDFTIKQ MRQGAFLVNC ARGGLVDEKA LAQALKEGRI RGAALDVHES
     EPFSFTQGPL KDAPNLICTP HTAWYSEQAS LEMREAAATE IRRAITGRIP DSLRNCVNKE
     FFVATAPWGV AEQQVHAELN GGAYRVAQPL PAISPGGLQD KMYT
//