ID   A0A3B4DL76_PYGNA        Unreviewed;      1114 AA.
AC   A0A3B4DL76;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Disabled homolog 2-interacting protein-like {ECO:0000313|Ensembl:ENSPNAP00000024208.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000024208.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000024208.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3B4DL76; -.
DR   STRING; 42514.ENSPNAP00000024208; -.
DR   Ensembl; ENSPNAT00000010706.1; ENSPNAP00000024208.1; ENSPNAG00000005291.1.
DR   GeneTree; ENSGT00940000165433; -.
DR   OMA; TWGSRSQ; -.
DR   OrthoDB; 22721at2759; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0048468; P:cell development; IEA:UniProt.
DR   GO; GO:0048731; P:system development; IEA:UniProt.
DR   CDD; cd04013; C2_SynGAP_like; 1.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF96; RAS PROTEIN ACTIVATOR LIKE-3; 1.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          569..761
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          1..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          860..879
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          887..959
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          985..1044
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        37..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1114 AA;  124295 MW;  F470011ED5D08186 CRC64;
     MGINKEPEIE QTSPPHEEEA AAQRNCPAEG EVEQPEDGNN PLSTYKWHTG AKSEASSQGT
     FERLEKGAAN KWSKMQNWRK ALSEDSGDKS TTAAMVKGGE SPTKSEKPVS SKKNPFRRAL
     SEPPGALLSS VLSPSTSASS EASGETAQKG KLRKYLHQVS QRLKRPRLQP RNNTEQDVSP
     VEPAPAALEP TQLSWSPPQD IPVWDINYCV LQDGQIIIPR EEEPLMRMRN RASSCLSSLS
     LQNLSESHTN LECTPDHVAP VSAPNSKAHS GGVKAKIKRR LQGGAQKKQL SQTGRSGSRE
     SLSIPVGIAE SLDLSADRTT VIRPVHSSIL GEKYCFEVIN SENNHCFGCS SAAERDRWIE
     NLRRTAQPNK DNCERTENSL SLWVYEAKDI PPKRRYYCEI HLDGTLFART SSRAVGKSSQ
     ASDGTTSGGA GGSGNQGGCQ LFWGELFELD NLPPVSQVTL HLFRDDDPKK KRHSKDDSVL
     HPLGSVALSL AEIKGRAFQE KWYSLVPYKT PVSGGMKDQL GSQASLRVKA RFQNLLVLPI
     EKYKEFAEYV TVGYVGMCSS LEPLLNVKDK EELAGALVHV LQSIGKAKEF LIHLGSAEVQ
     RLGENKALIF RENTLATKAI DEYMKLVGQK YLIDTLGDII AQLYASSESC EVDPQKCSSS
     DLPVNQQHLK KTCSEVVQQI TEMHRSFPVE LNEIFSSWLS DCEEQGREEI GHRLITASLF
     LRFLCPAILS PSLFGLTQPY PEPNTLRTLT LTAKVVQNLA NFTPFGEKEE YMLFMNDFLE
     QHWELMRGFL RMVSNPDSEL DMARFDGYVD LPLRLAVLHG LLVDIISPMA QDTIDSLQPL
     PSILNQITDH LGPDAPRITC SSFSLGQPKP TYVPPRDLAK YSPLNKSLQH LPTDSKPSHS
     RDRQRKQVTR TQSVPTRKHF HPLKRQTSSE ELQKNQPEPE EGAGPQMAIS SPQDNTRAKG
     SSIPWVILNK EPNQTKTEQE EMSLLDRHVQ ELSELRQRVE EALDTELDVA KRLEEYIAQS
     QGQNAQLQAE VQELRNLLAT REEQLASATF RLGVIEEERE EDERKLTIAL AAAERMNVLE
     EQFAGLLNDM QKLNMAHNDD HLTQDRRNTV SGFV
//