ID A0A3B4DM89_PYGNA Unreviewed; 1653 AA.
AC A0A3B4DM89;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=ATP-binding cassette sub-family A member 5-like {ECO:0000313|Ensembl:ENSPNAP00000024049.1};
GN Name=ABCA5 {ECO:0000313|Ensembl:ENSPNAP00000024049.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000024049.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000024049.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_017559122.1; XM_017703633.1.
DR Ensembl; ENSPNAT00000011112.1; ENSPNAP00000024049.1; ENSPNAG00000008549.1.
DR GeneTree; ENSGT00940000158172; -.
DR OMA; ITYFMGY; -.
DR OrthoDB; 6951at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF36; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 5 ISOFORM X1; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 219..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1021..1042
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1078..1098
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1104..1126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1138..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1179..1198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1207..1228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 481..716
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1289..1532
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1653 AA; 185879 MW; 59B603EB74F3E29D CRC64;
MQPLNRRDAG VWHQTRSLLY KNLLIKWRTK QQSLQELILP LLLLGLLILI STLNPHISYG
SISTTELEDD AYLSLKGLGY TPITNVTSQI MEDVAQELHM QDRLEMFSTE EDLENASLYE
PLGYVGVVFL DNLSYRLRFP YNQLPPPSDY TESIANCYAN YLNCRAANYW YSGFIRLQSL
IDAAIIQMQT KRSVWRELTV RVVMMGHPGS VEVQKFPHAL ISIYLVLAFT PFVSFLIVNV
AAEKEHRLKD TMSMMGLYDT AFWLSWGLLY AALVTTMSVL MAVIATWTPL FSNSNFLVIF
LLIFLYGIST IFFSFMLTPL FKKPKFASTM GSMLTLVFGC LSLFTVLMRD FPQPAVWVLC
LLSPSAFSIG IAQVVYLEAQ GDGAVFSTLA NGPHALYVPL LMLFVDCILY LLLAVYLDQV
MPGEFGMRRS VIYFLKPSYW TTRSKRYVEV SSVYEVEVNG TPTVDESVEP VSPEFRGKEA
IRICNIRKTY KEKDNTVEAL RGLTFDIYEG QITALLGHSG AGKSTLMNIL CGICPPTEGS
ATIYGSPVAK IADGAEMKQL VGICPQFNII FDVLTVEEHL RIFAAIKGIL PCDIDSEVRK
VLKDLDLEKI MDAQAKNLSG GQKRKLSVGI AILGDPKILL LDEPTAGMDP VSRHQVWSLL
KSRRAGRVTV LSTHYMDEAD ILADRKAVIS QGQLKCVGSS LYLKTKCGVG YHLRMSVTEV
CEVDSLASLV KQHVPKAQLS RQQEAELTFT LPFESMETFP GLFAELDCRP DLGIINYGVS
MTTLEDVFLR LEAEAEVDQA DYSVFNQDKV EEEGDASSLD DMDQRLLTFS ESRQDAVKGH
ALWRQQFSTV AWLHMLNLQR ERKPIIYNVT LFLVFLTAVL VLSLATGNIQ IHSPDRRFQP
IYLLHRNEAS HKYATSLLVL NSSDSDISGF VHNLEAQDIK VEMMRKPDYM SAAPHSAAIN
VTGSSKGFSY ILAFNSTTVH SLPMAVNVLS NALLRGFNGT GHISTWSKPF DYQIPDSTSY
ALVYIEAVIL GMLAAGMPAY FAMDHTRDRE IKCRSTLRIS GMVPSAYWCG QAAVDIPFYY
LILICMTSTL FAFHSTNLLS NSNIMSVILC LIGFGPAMIL FTYCISFMFA KVQSNRDFFS
VVSMMVCVVS ASMVQLAFVN DNPGLTRALH NTLCFFNPLY PLIACLNCIT KATFLLSFHE
EFLWKNLLIA VIAPYLQCIL LLFLLRWLEI RYGGQTMKND QLCRISSKAN CKVQRNPEEN
EDEDEDILVE KARVKEALTC QCCEEKPVVV VSNLRKQYSG KKEGFSLGKR RKVAAKNISF
CVRKGEVLGL LGPNGAGKST IMHMLSGDTN PTAGQILMGD YSTEFRPVDN PLEHVGYCPQ
VNPLWPRVTL QEHLQIYAAI KGLRHNDVPN IIRRVVNALE LKEHLHKQAK NLSAGLKRKL
CFALSMLGNP QIVLLDEPSS GMDPKSKQRM WRAIRAAFKN KQRGAILTTH YMEEAEAVCD
RVAIMVSGQL RCIGSIQHLK AKYGRGYSLE IKLREELTGL QQVALLHKEI LRIFPHAARQ
ESFATLMVYK IPMEDVKSLA QAFSRLESAK QNFNFEEYNF SQCTLEQVFM EFAKEQENEE
EEVGSLSTTF QWQRLRQDGS ASFNHTDSIV HQL
//
