ID   A0A3B4DN26_PYGNA        Unreviewed;       885 AA.
AC   A0A3B4DN26;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Amyloid beta precursor protein binding family B member 2 {ECO:0000313|Ensembl:ENSPNAP00000024873.1};
GN   Name=APBB2 {ECO:0000313|Ensembl:ENSPNAP00000024873.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000024873.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000024873.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4DN26; -.
DR   Ensembl; ENSPNAT00000009027.1; ENSPNAP00000024873.1; ENSPNAG00000009758.1.
DR   GeneTree; ENSGT00390000000002; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR   CDD; cd01272; PTB1_Fe65; 1.
DR   CDD; cd01271; PTB2_Fe65; 1.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR039576; APBB1/2/3.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR14058; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B; 1.
DR   PANTHER; PTHR14058:SF11; AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 2; 1.
DR   Pfam; PF00640; PID; 2.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00462; PTB; 2.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF51045; WW domain; 1.
DR   PROSITE; PS01179; PID; 2.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
FT   DOMAIN          345..377
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          545..685
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          715..841
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..196
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..285
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..340
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..403
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        417..436
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   885 AA;  96716 MW;  2D63ABE51AB7D020 CRC64;
     MMSVCVPSPC NSSPSVDVAN HNGPSVTPPT SLSLRSSHNQ LLSGDVVKQG QATPPKCRKK
     YALTSIQSAM GLSDGPAPPS SSPSASSNTA SANNLKLAKN GANQMRKAAE LHDQNKNTTN
     EDEVGNPTED SELIVDQELH ADLDLSIDSR TELDHTQTDD SDSISELAKE DTSDFVNDDD
     AIEEDQVQDS NTNPFEEDSD DLLILSEKTE LTLDRKSPQF RKAKSLLESH GDDLTLDDPS
     AEDEDITQPL LKEQKNPSPP SPRKQRSPED TPLLSVGSSS ASSSPETKKD RPRTGAKTDR
     ALNRIQNLPH SDEESSWTTL SQDSASLGSP EENDIWGEQS FQTDPDLPPG WKMMTDMAGI
     YYWHIPTGTT QWERPGPCHP APTGPNHDTR KHSLGSLSPS PTPDHEGSHA DVFFGASGRS
     GSTTSDSSND PVPLASSSCL EPAPLLSSNS SSSSEANVPS CGFVNSCYFP RSSSLQIMPE
     KDRHTEAHHR EEDKDLQAAT VNPDPSLKEF EGATLRYASL KLRHPAPVEE EDSSSINSDP
     EAKCFAVRSL GWVEMAEEDL APGKSSVAVN NCIRQLSYCK NDIRDTVGIW GEGKDMYLIL
     ENNMLNLVDP MDRSVLHSQP IASIRVWGVG RDNGRDFAYV ARDKDTRILK CHVFRCDTPA
     KAIATSLHEI CSRIMAERKN AKAMAGGSLQ DRSHAGLDVP LQAEFPTPKT ELVQKFQVLY
     MGMMPVARPI GMDTLNSAVD SLITSSVRDE WTPVMLNVAD ATVTVIKEKE EEEVLVECRV
     RFLSFMGVGR DVHTFAFIMD TGNQHFECHV FWCEPNAGSV SEAVQAACML RYQKCLVARP
     PSQKACSQVP PSDSVTRRVS TSVKRGVLSL IDTLKQKRPV TELPQ
//