ID A0A3B4DN74_PYGNA Unreviewed; 366 AA.
AC A0A3B4DN74;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Protein-tyrosine sulfotransferase {ECO:0000256|RuleBase:RU365018};
DE EC=2.8.2.20 {ECO:0000256|RuleBase:RU365018};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000024915.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000024915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic
CC motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as
CC cosubstrate. {ECO:0000256|ARBA:ARBA00003886,
CC ECO:0000256|RuleBase:RU365018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine
CC 3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein];
CC Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339,
CC ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000411,
CC ECO:0000256|RuleBase:RU365018};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the protein sulfotransferase family.
CC {ECO:0000256|ARBA:ARBA00009988, ECO:0000256|RuleBase:RU365018}.
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DR RefSeq; XP_017549239.1; XM_017693750.1.
DR RefSeq; XP_017549240.1; XM_017693751.1.
DR AlphaFoldDB; A0A3B4DN74; -.
DR STRING; 42514.ENSPNAP00000024915; -.
DR Ensembl; ENSPNAT00000008926.1; ENSPNAP00000024915.1; ENSPNAG00000009731.1.
DR GeneID; 108425232; -.
DR CTD; 8459; -.
DR GeneTree; ENSGT00390000006030; -.
DR OMA; MENIAPM; -.
DR OrthoDB; 5391764at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008476; F:protein-tyrosine sulfotransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR026634; TPST-like.
DR PANTHER; PTHR12788; PROTEIN-TYROSINE SULFOTRANSFERASE 2; 1.
DR PANTHER; PTHR12788:SF6; PROTEIN-TYROSINE SULFOTRANSFERASE 2; 1.
DR Pfam; PF13469; Sulfotransfer_3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT REGION 344..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 41106 MW; A6AC92B67DBF201A CRC64;
MRLSVRRGAT LLLCVFGLYI AGNALYKVFM CQSRLARSRK VSVLVKGSNQ TRFHYSHLSP
MVFVGGVPRS GTTLMRAMLD AHPLIRCGEE TRVIPRLLGL RQGWKRHGEE RRSLEEEGVT
QETLDAATMA FLLEIIARHG EPAPLLCNKD PFTLKSSSYL SDIFPNSKFI LMLRDGRASV
HSMISRRVTI GGFDISSYRD CLTKWSHAIE AMLFQCTLVG PNRCLTVRYE SLVLQPRTTM
VKVLRFLGVP WHEGVLHHEL AIGQPGGVSL SRIERSTDQV IKPVNLEALT RWVGHIPADV
LKDMENIAPM LSRLGYDPSA NPPDYGQPDP EVINNTEKVL RGDFKLPANL KRPSHESMSE
ASHTRR
//
