ID A0A3B4DQ33_PYGNA Unreviewed; 1487 AA.
AC A0A3B4DQ33;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Calmodulin-regulated spectrin-associated protein 1-B-like {ECO:0000313|Ensembl:ENSPNAP00000025221.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000025221.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000025221.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR RefSeq; XP_017540975.1; XM_017685486.1.
DR STRING; 42514.ENSPNAP00000025221; -.
DR Ensembl; ENSPNAT00000008148.1; ENSPNAP00000025221.1; ENSPNAG00000010194.1.
DR GeneID; 108413125; -.
DR CTD; 402833; -.
DR GeneTree; ENSGT00950000182975; -.
DR OMA; WPEVANS; -.
DR OrthoDB; 2918432at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF3; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}.
FT DOMAIN 235..350
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1352..1486
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 422..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 811..841
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 422..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..672
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1070
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1487 AA; 165326 MW; 0349594179120B15 CRC64;
MDVGAAGGVD GGPRRADSVE GGLEIIPLEL YDSARAKIDA NLRWLFAKAY GEAHVPADLR
DPFYTDQYCV EHIKPPVLTL LLSSELYCRV CVLLLKGDQT ASLSSHQSVL QALARHGIYA
REPDDTPVTH DDLSSTPIKM SSHIPLIDAL MLAWTVEMMS IERVVSSVKR FSTFSASKEL
PFDVEDAMLF WINKVILKTR EISEKELKLK QHLMESPCHQ KPDFMHALAH CMLEPVELSR
VVRYRRDHLS GRCLPHMPLV EDLMKDICDG AALLTVIHYY CPDFMRLEDI CLKEVLSISD
SVYNIQLLRE FSNEYLDRCL YLRPEDLLYA PPVLKHNVMV FIAELFWWFE VVRPDFVKPR
DPQEIKEARA SVQAKSSRPL VPISNATKRS FLSTSPSVDS MVSGSAHDTC IRYYLHPEES
ASTSVTKVSP SHSPSHPLLP LRQRQQKPVQ GEETAEFRNR SSSLSRMDGH SPGSRLAWME
RRQRPLSQME MEWERLCGDN ISLARSISKD SLASNVVSIT PRHHINGQPL PHTACSHDFE
DQEEELVAVI SSGGVATFRE SRPESFFLEP LQPAVLRPNK EKSVVVSKRD ESGEGRGQRR
RAVHTPTEHT AINQTFTTVS TVEPEGSPQS GGFFLHGKSE CVRSSPVGVW VGGVSDSEFE
EEEEEAEDDD VEERDIAKAH IRKLLGHGQE EEESAKLREE VRGREREDKE GASGRSSPCP
STLSQASSTS TGAGHTRQSS PCRSTFSQAS SASSRMTSFA ERRLHRAVTP DGFYSGCSSQ
TSTPDGSESA PFPPQAGDRA SPSPGARGGV ASELIHLRMQ LEEKRRAIET QKKKMERLSA
RQRLKLGKAA FLHVVKKGRG DTLPRPVKQE VLKEKETEKE MAKDDSYVEA LKAKAKAKET
EPSPDKESRQ LAEISAAPPA TLEVDNRVSE GEAWEEGGGE LDLSECNRSI ELLNEAIGSI
QQQMMQLSVQ QDLLMRQTAL SPTQEKPQSP SEPNEPKLRP SVQFVEISTA TRRPPKLSSG
RTPRTKPAEL KLSKGSKVNT GDPRPSPVSR TPRAENEEDG VSKDVGDKAN GRSLARSLAR
NATFRLHDAA NRRTDGPESP KAEPPTVEPS QAEPGRERSG SGGSGKENVP VPCEENRTKG
QLIEVDLSDL TNPESSAEPE GEQKSGLGFF FKDDQKAADE LAKKRAAFLL KQQKKAEEAR
LRKQQLEAES ELKRDEARRK AEEERVRKEE EKARRELIKQ EYLRRKQQEL LEEQGVAKPR
PRHRKPRPKS LHRRESGNAT PVGLCAAPSG SSLSLASAAT EADSITSGGG SQRGESVESF
PMLSRNASRN VERDWDNGST ASSVTSVAEY NGPRLFKEPS AKSNKPIIQN AIAHCCLAGK
VNEAQKNAIL EEIERCESNH LMILFRDGGC QFRALYAFAP DTEEILKLVG TGPRAITRKM
IDKLFKYSSD RKQFTVIPAK TVSVSVDAIT IHNHLWQVKR PGSSKRK
//
