ID   A0A3B4DQS0_PYGNA        Unreviewed;      1150 AA.
AC   A0A3B4DQS0;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Cingulin {ECO:0000256|ARBA:ARBA00044075};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000025441.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000025441.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Probably plays a role in the formation and regulation of the
CC       tight junction (TJ) paracellular permeability barrier.
CC       {ECO:0000256|ARBA:ARBA00043864}.
CC   -!- SIMILARITY: Belongs to the cingulin family.
CC       {ECO:0000256|ARBA:ARBA00038467}.
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DR   AlphaFoldDB; A0A3B4DQS0; -.
DR   STRING; 42514.ENSPNAP00000025441; -.
DR   Ensembl; ENSPNAT00000007608.1; ENSPNAP00000025441.1; ENSPNAG00000010572.1.
DR   GeneTree; ENSGT00940000154489; -.
DR   OMA; HWREMFQ; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR   Gene3D; 1.10.287.1490; -; 2.
DR   InterPro; IPR002928; Myosin_tail.
DR   PANTHER; PTHR46349:SF4; CINGULIN; 1.
DR   PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR   Pfam; PF01576; Myosin_tail_1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054}.
FT   DOMAIN          362..618
FT                   /note="Myosin tail"
FT                   /evidence="ECO:0000259|Pfam:PF01576"
FT   DOMAIN          886..1103
FT                   /note="Myosin tail"
FT                   /evidence="ECO:0000259|Pfam:PF01576"
FT   REGION          23..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          72..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          709..737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          804..825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          983..1025
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1110..1150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..140
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        986..1000
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1002..1025
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1134..1150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1150 AA;  130790 MW;  2B4FBDC9166895E6 CRC64;
     MSAPASGRKT PVDYGVQIRF IKDLHDTGGG HGGQSRREGS GKSSSRYGVA VRVQGIAGQP
     YVVLKEGEKG DSYGVQLRTQ PHNAPPPYNS LPRRRDDGSA QGQYFATPDG SPLRRAQSHG
     SLLDREDGDN FDRDIRRPPG DGRSGSYGNL DAGIGVGSER ERTRGGMQRN QWGGSHQMGL
     NGSVERETLR GGSGHYSSRS GPNSNQTPFN RPIMSSSGQA GSVGGSSRGS SPALDAGTRP
     NTASSTLSST PSVALNTYSS PPSSSPASAY SSLGRTSGSI AKVAAVPSSA VANDWSSVDA
     HVTPDLLMDQ GQSSGSEFTS EEDQIQQMIY SVLRKSSESD AAIKRRARII CDKIQALKVN
     RPDSTLKTQL EQSLDENVHL QEQLNRKKTE LDQTHTLTQL RMDRENAESR VRQLEDQLAG
     LQEELRRETH NRAQNDSIEA ELLALRTELA EAAALHQKQD DTLRQREREL TALKGALKDE
     VSTHDREMET LREQYSQDME KLRASMEQVS QFQSQASIEA ERQRVNSTVR SLQQQLEECK
     EEGDHWRGQF QSTREDLRNT KQLLQARLEK EEFEEELKEL QEKLNSMKHQ IPDVKQSQTL
     NQSQELERCR ANLKQAQAEV NKLKGDLDKK TMEIISLKRT NQELDAEQKY EIDRLKDQKR
     KDREELAKVH EKAKQLADPA LVESLRGELN AVLGEAEKLR KQLLSADKEL QSERDRVNSS
     QTHIHTLTQE HKELEENNTR LKEKITRLES QLQERVSQSL EAEQELQEES RRLRQQLDEA
     KRLNGKLGQE RDELTRVLDE RDKDRETLRK ENSQLDEQKR QHEKTVDKLN REIERLSADS
     SQSVQLLQSQ LDEQKEKWRK EQQDIQKSHK DKISELEKVN VTLRSLQEEK KELLSCCEER
     DNAVLDKELL TNRLRHLEGE LESQRSSYNE RSREIRSMEA RADTHLLIEQ LRSELMQERS
     SKQDLELDKN ALERQLKEYK SRVAEMEGQS RSSAGVSQLE SRLQEMEERL RAEEEKNSAL
     SSQRRVERKL KELTITLDEE RQQQTEQRDQ LALRVKALKR QVDESEGEVE RLDGLRRKAI
     RDMEEQMEQK EALQSRVTAL ENEVRKIQQA RHISMDSSAL SSDDDDDDGL YDPSSITSIL
     TESNLQTSSC
//