ID A0A3B4DR63_PYGNA Unreviewed; 406 AA.
AC A0A3B4DR63;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ras association domain family member 5 {ECO:0000313|Ensembl:ENSPNAP00000025586.1};
GN Name=RASSF5 {ECO:0000313|Ensembl:ENSPNAP00000025586.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000025586.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000025586.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_017568521.1; XM_017713032.1.
DR AlphaFoldDB; A0A3B4DR63; -.
DR STRING; 42514.ENSPNAP00000025586; -.
DR Ensembl; ENSPNAT00000007238.1; ENSPNAP00000025586.1; ENSPNAG00000010749.1.
DR GeneID; 108436506; -.
DR CTD; 83593; -.
DR GeneTree; ENSGT00940000159288; -.
DR OrthoDB; 4260488at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20886; C1_RASSF5; 1.
DR CDD; cd21892; SARAH_RASSF5; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033614; RASSF1-6.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22738:SF9; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR22738; RASSF; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF16517; Nore1-SARAH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50951; SARAH; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 113..160
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 268..352
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 354..401
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 373..400
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 406 AA; 45487 MW; 450F143CF40916F6 CRC64;
MASVTLRQHP AQHHLEPRLA SHASRRVARK SSRKRSAERA ARENANANNN GAFASCDADG
WRTCADGGLP EGLRLRGDVV RRARSERHRR EAWSIFSWSP PEPRAKTDSA GQGHLFNTHS
VVKRDFCDAC GKIIRSAARR CENCSYTCHL ECEGLVQLDC NQSDRQTEET PTDSPCTVYS
TSSVVKNAAK EDEEDNAKSL SEEQIKAKIE EYNSKVSENG MKLADDGSYT GFIKVHLKLR
RPVTVLSPDG KGPGCSPAAD GPERRTSFYM PSDTVKQIHV SSINTVSEVI QGLLKKFMVQ
DNPHKFALYK QTHRDGQDLF QKLAGSEQPL CLRLLAGPDL ESLSFVLKEN ETGDVEWHAF
SVPELQNFLT ILNKEESERM KQVKMRYEAY KKKLLEALRE VQSNPG
//
