ID A0A3B4DR70_PYGNA Unreviewed; 247 AA.
AC A0A3B4DR70;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Interleukin-1 {ECO:0000256|RuleBase:RU003753};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000025454.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000025454.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Secreted, extracellular exosome
CC {ECO:0000256|ARBA:ARBA00004550}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000256|ARBA:ARBA00010448,
CC ECO:0000256|RuleBase:RU003753}.
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DR AlphaFoldDB; A0A3B4DR70; -.
DR Ensembl; ENSPNAT00000007580.1; ENSPNAP00000025454.1; ENSPNAG00000001603.1.
DR GeneTree; ENSGT00950000182943; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR020877; IL-1_CS.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR10078:SF30; INTERLEUKIN-1 BETA; 1.
DR PANTHER; PTHR10078; INTERLEUKIN-1 FAMILY MEMBER; 1.
DR Pfam; PF00340; IL1; 1.
DR PRINTS; PR00264; INTERLEUKIN1.
DR PRINTS; PR01359; INTRLEUKIN1B.
DR PRINTS; PR01357; INTRLEUKN1AB.
DR SMART; SM00125; IL1; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
DR PROSITE; PS00253; INTERLEUKIN_1; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Secreted {ECO:0000256|RuleBase:RU003753}.
SQ SEQUENCE 247 AA; 28103 MW; D798FF26181EC91A CRC64;
TDYNYFCLFF INGRCDLHKG LRIEISEQPH TMRQVTNIII ALQKFKQVRS TEFTDHELFN
IIIENIVEGH IIVNCEFSRT YNKQDRVIQC TVCDGLKKSL VQSQGTPNLL AVTLRGGNSN
RSVGINLSTY TTPGCKATNG QPICLKIAQS NLYLACTKES GTSSQPHLIL EDVKDEETLK
TIEENDGMER FLFFRKVTGG SINTFESVKY PHWFISTSKN ESMPVDMCVE EDTSRQKIFT
LQDQKVI
//
