ID   A0A3B4DS82_PYGNA        Unreviewed;       825 AA.
AC   A0A3B4DS82;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=HECT domain E3 ubiquitin protein ligase 3 {ECO:0000313|Ensembl:ENSPNAP00000026320.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000026320.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000026320.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3B4DS82; -.
DR   Ensembl; ENSPNAT00000005404.1; ENSPNAP00000026320.1; ENSPNAG00000011696.1.
DR   GeneTree; ENSGT00940000159923; -.
DR   OMA; PAWDYTL; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR004939; APC_su10/DOC_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR042469; HECTD3.
DR   PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR   PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR   Pfam; PF03256; ANAPC10; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM01337; APC10; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS51284; DOC; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          186..363
FT                   /note="DOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51284"
FT   DOMAIN          497..821
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        787
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   825 AA;  93710 MW;  66B51EA5C059F9BA CRC64;
     MSPGENPHLL LGRIRCLNRC IECFRRGEAL PESLCFVPKE VCYKICKDSS AGSGSSSSST
     AKCTIEPKKG TCIRTSGEEY YNSHGLWVKI SKEQLEEYRN GVEMDEGWIL ACKHAEGGHR
     LVPVEAPDTA SREQQLFGYD HKPCNRWEQV VDAENCLYLG GKPRVAEYDE AAVQKLRYVP
     ATWTFECDED LVHYFYDHVG KEDENLGSVK QCVSSIDVSS CSVSSCLTDG DTETYWESDG
     MQGQHWIRLH MKRGTVVNKL ILTVDSTDDT YMPKRVTVFG GEGDNLKKYG DVNIDENLIG
     EVCVLEDMTI HLPIIEIRIE ECRDGGIDVR IRGLKIKSSC ERDLGLNADV FQSPHLVRYP
     RLEGTPPDVL YRRALVILRF ISLLDSLLPH LVPAWDYSLG TFNQIKSIKQ FLLLSKRRST
     LIIQCLKDSE SSKPNFMPRL YINRRLAMEH RDNPSLDPTC KNAVFTQVYE GLKPSDKYEK
     TLDYRWPVRH DQWWECKFIA EGIIDQGGGF RDSLADMSEE LCPSSAECAM PLPFFTRTSN
     QGAGEARDFY VPNPSCREFH KLEWIGQLMG AALRGKDFLV LALPGLVWKQ LTGEAVSWSE
     DFPAVDSVLV KLLEAMEHMD KETFDFKFGQ ELVYSTPLSD GRLVELIPGG GSVVVRYEDR
     MEFVRLVQKA RLEESREQIA AIQAGLLKVV PQAVLDLLAW QEVEKKVCGD PEITVEALKR
     LTRYEDLEPT DIRVQYLWEA LTNFTNEDRS RFLRFVTGRS RLPAPIYIFP DKQGSETTDA
     LPQSSTCSST LYLPKYPSAK VCEEKLRYAA YNCVAIDTDM SPWEE
//