ID A0A3B4DSM0_PYGNA Unreviewed; 1048 AA.
AC A0A3B4DSM0;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Unconventional myosin-Ic {ECO:0000313|Ensembl:ENSPNAP00000026453.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000026453.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000026453.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_017569389.1; XM_017713900.1.
DR AlphaFoldDB; A0A3B4DSM0; -.
DR STRING; 42514.ENSPNAP00000026453; -.
DR Ensembl; ENSPNAT00000005066.1; ENSPNAP00000026453.1; ENSPNAG00000001980.1.
DR GeneID; 108437060; -.
DR CTD; 567536; -.
DR GeneTree; ENSGT00940000166539; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0060171; C:stereocilium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF861; UNCONVENTIONAL MYOSIN-IC-RELATED; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}.
FT DOMAIN 29..714
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 868..1043
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 591..613
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 122..129
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1048 AA; 120759 MW; 9F5025B71BBA39F5 CRC64;
MRYLGREVEV EGIVRLVMES GLSARDRVGV QDFLLLDNYT SEAAFIENLR RRYKENLIYT
YIGSVLVSVN PYRELEIYSK QHMERYRGVN FYEISPHIYA LADNSYRAVR TERKDQCILI
SGESGAGKTE ASKKVLQYYT TMCPTRNNTQ SIRERLLQST PVLEAFGNAK TLRNDNSSRF
GKYMDVQFDY KGAPIGGHIL NYLLEKSRVV HQNHGERNFH IFYQLLESGD GALLKRLGLD
RTNPQQYHYL VKGNCPRVSS ISDKNSWKVV SKAFTVIGFN EEEVEELLKV VASVLHLGNT
QFGEDEYGET HLTTEMPIKY VSELLGVEGS YLSEALTHKK IVAKGEEMIG PLSLEQAVSA
RDALAKAIYG RTFTWLVQKI NQSLAFQDEV YYTSKCSSVI GLLDIYGFEV FQNNSFEQFC
INYCNEKLQQ LFIELTLKSE QEEYEAEGIG WETVEYFNNK IICDLVEEKF KGIIAILDEE
CLRPGDACDL TFLEKLEDRL GGHAHFVTHK LANGKIRKAV GREEFRLLHY AGEVNYNING
FLDKNNDLLY RNLKEVMCQS SNQIMKECFQ TDELTDQRRP ETAATQFKLS LAKLMDILMS
KQPSYIRCIK PNDAKQPGRF EEVLVRHQVK YLGLMENLRV RRAGFAYRRS FEAFLQRYKP
LCPDTWPNWQ GKLSDGVSTL VKHLDYKAEE YKLGRSKIFI RFPKTLFLTE DALELKKPTI
AIILQKNWRG YRERAKYHRI RNAVIMIQSW WRGVKGRRRA KRRRQAADTI RNLIKGFILR
NEPRCPDNEY FLDHVRFSFL MTIKRNLPKS VLDRTWPRPP PSLTEASVHL HRLCIRNLVN
DYCRKIQPEW RNQLEQKVVA SGIFRGQKDN YPQSVPRLFV GTRLENEEIN LKVRQTLGTD
NKVKYGVVVT KYDRHGFRAR PRQLLLMGSG VILVQESKIK QRIDYSSLLG ISVSSLSDGF
FILHVPPADS KQKGDLVLQC DHVIEAVTKL AVMADKIHSV NISQDSIKFA IARGKEGVID
FTYGAELRVV KTKNGHLAVT APQSFSSV
//
