ID A0A3B4DTU5_PYGNA Unreviewed; 983 AA.
AC A0A3B4DTU5;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Connector enhancer of kinase suppressor of Ras 2 {ECO:0000313|Ensembl:ENSPNAP00000026404.1};
GN Name=CNKSR2 {ECO:0000313|Ensembl:ENSPNAP00000026404.1};
OS Pygocentrus nattereri (Red-bellied piranha).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Pygocentrus.
OX NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000026404.1, ECO:0000313|Proteomes:UP000261440};
RN [1] {ECO:0000313|Ensembl:ENSPNAP00000026404.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_017579901.1; XM_017724412.1.
DR AlphaFoldDB; A0A3B4DTU5; -.
DR Ensembl; ENSPNAT00000005177.1; ENSPNAP00000026404.1; ENSPNAG00000001903.1.
DR GeneID; 108443642; -.
DR CTD; 561623; -.
DR GeneTree; ENSGT00940000156709; -.
DR OrthoDB; 5406576at2759; -.
DR Proteomes; UP000261440; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01260; PH_CNK_mammalian-like; 1.
DR CDD; cd09511; SAM_CNK1_2_3-suppressor; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR049628; CNK1-3_SAM.
DR InterPro; IPR010599; CNK2/3_dom.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF21; CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2; 1.
DR Pfam; PF06663; CNK2_3_dom; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
FT DOMAIN 11..76
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 84..178
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 215..270
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 520..619
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 266..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..663
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..849
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 983 AA; 110564 MW; B58A9447053D2985 CRC64;
MALVMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKVG GDQLLRITHQ ELEDLGVSRI
GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ NFITGRRRSG HYDGRTTRKL
PNDFLTSVVD LIAAAKSLLA WLDRSPFAAV TDYSVTRNNV IQLCLELTTI VQQDCTVYET
ENKILHVCKT LSGVCDHIIS LSSDPLVSQS AHLEVVQLAN IKPTEGLGMY IKSTYDGLHV
ITGTTEGSPA DRCKKIHAGD EVIQVNHQTV PVAPKSPTSS SATPTSTIST PSKRDSSALQ
DLYIPPPPSE PYTPRDEQGN LPGDDRGQGG IPAAKGSESP NSFLDQEYRR RFPLMEEEAV
LYCYEYDPNR GGPPSRREST PTYGRLRPIS MPVEYNWVPD YEDPARLKRE GRRENSMLRY
VSEEKVPEEY LTSRSAKRDT GKRTKKKSEK GGSPAHYSLL PALQMEVLRQ ESMSTPSSDS
TSLYHTFQGS SLLSKSKKKS KGGPLSSISK RRISCKDLGR GDCEGWLWKK KDAKSYFSQK
WKKYWFVLKD ACLYWYMNEE DEKAEGFVSL PEFKIDRASE CRKKYAFKAC HPKIKSFYFA
ADGVDDMNRW LSRLNMAAAG YAEREKIRQE QADYWSESDH EDNETPSTPK QDSPPPPYDT
YPRPPSMTCA SPYLEPKHGR LSSTETSQSR SSHEEYRSEP PGGGSSSGGG SPARKSASQR
RSWQDLIETP LTSSGLHYLQ TLPLEDAVFC EPGVGLSPEY RRQSTLPAQR TLLQEHYGPF
PMAEGERLRD PVTAGGKPRS FTLPRDSGLH TLLTPSSSMA EQRDPQRREL SRSHCIDNGG
EQDQERQGHA DSLGDLYRAL ERASLSPLGE RRLSTRLEYK HSFVRRCNDP LLNDKVHRLR
ILQSTLKDRE GEIAVIDKLL AKPKLSSSEF QEWKRTYLEL FSADAKQERQ SSPVSEPSPG
STPEPTPRAP SLSHTHSYIE THV
//
