ID   A0A3B4DUJ9_PYGNA        Unreviewed;       955 AA.
AC   A0A3B4DUJ9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Sodium/calcium exchanger 1-like {ECO:0000313|Ensembl:ENSPNAP00000026761.1};
OS   Pygocentrus nattereri (Red-bellied piranha).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Pygocentrus.
OX   NCBI_TaxID=42514 {ECO:0000313|Ensembl:ENSPNAP00000026761.1, ECO:0000313|Proteomes:UP000261440};
RN   [1] {ECO:0000313|Ensembl:ENSPNAP00000026761.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC         Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00033667};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR   AlphaFoldDB; A0A3B4DUJ9; -.
DR   STRING; 42514.ENSPNAP00000026761; -.
DR   Ensembl; ENSPNAT00000004355.1; ENSPNAP00000026761.1; ENSPNAG00000012101.1.
DR   GeneTree; ENSGT00940000164137; -.
DR   Proteomes; UP000261440; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   GO; GO:0042044; P:fluid transport; IEA:Ensembl.
DR   GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR   Gene3D; 2.60.40.2030; -; 2.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR038081; CalX-like_sf.
DR   InterPro; IPR003644; Calx_beta.
DR   InterPro; IPR004836; Na_Ca_Ex.
DR   InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   NCBIfam; TIGR00845; caca; 1.
DR   PANTHER; PTHR11878:SF73; NCX4A; 1.
DR   PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR   Pfam; PF03160; Calx-beta; 2.
DR   Pfam; PF01699; Na_Ca_ex; 2.
DR   Pfam; PF16494; Na_Ca_ex_C; 1.
DR   PRINTS; PR01259; NACAEXCHNGR.
DR   SMART; SM00237; Calx_beta; 2.
DR   SUPFAM; SSF141072; CalX-like; 2.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Calcium {ECO:0000256|ARBA:ARBA00022568};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          397..498
FT                   /note="Calx-beta"
FT                   /evidence="ECO:0000259|SMART:SM00237"
FT   DOMAIN          527..626
FT                   /note="Calx-beta"
FT                   /evidence="ECO:0000259|SMART:SM00237"
SQ   SEQUENCE   955 AA;  104965 MW;  FFA3BA63C4FDE550 CRC64;
     MLHICLRFPP YSFAPCLSTV LLFLLGLTEP LQASSDMYQS PPGNCSGKSS CSEGVVLPVW
     NPQNPSVGDK VARAIVYFVA LIYMFLGMSI IADRFMSSIE VITSQEKEIT IKKPNGETTT
     ATVRIWNETV SNLTLMALGS SAPEILLSVI EVCGHNFEAG DLGPSTIVGS AAFNMFIIIA
     ICVYVVPDGE VRKIKHLRVF FVTAAWSIFA YIWLYLILSV FSPGVVEVWE AVLTFLFFPI
     CVVQAWVADR RLLFYKYVHK RYRADKNRGI IIETEGDGMF TKMDMEMDGQ GANSHHKEVL
     DGMLAGVEEG GGGGAGGGGG EEEEARREMA RTLKELKQRH PEKDMEQLIE MANYQVLVQQ
     QKSRAFYRIQ ATRMMIGAGN ILKKHAADQA RKVVSCHEAN AQEEDPHTIY LEFEPSHYQC
     FENCGSLKLA VGRHGGDSGC TVKVDYRTED GTANAGSDYE FAEGTLVFKP GETIKELTVG
     VIDDDIFEED EHFYVHLSNP RVVHRAEVSV LDPNAVPKAA LGSAHTATVT IYDDDHAGIF
     TFESASTRVS ESVGVMQVKV HRTSGARGKV AVPYHTTEGT AKAGEDYEEV AGKLEFLNDE
     TMKILEVKII DDEEYEKNKT FTIHLGEPVL LEIGQKHGQE TFSFGQDYLP LKHHLKVSLC
     FPTGDSNDNK PAVGVEEEEV AKMGCPSLGE HTKLEVVIEE SYEFKNTVDK LIKKTNLALV
     VGSSSWREQF VSAVTVSAGD DDEEESGEER LPSCFDYIMH FLTVFWKVLF AFVPPTEYWN
     GWACFFVSIS LIGVLTAVTG DLASHFGCTI GLKDSVTAVV FVALGTSVPD TFASKVAAIQ
     DQYADASIGN VTGSNAVNVF LGIGVAWTIA AVYWHSKGQH FTVPPGSLAF SVTLFTILAL
     MCVLMLLYRR RPSVSGGELG GPRTAKLLTA LLFLSLWLIY ILLASMEAYC NLPGI
//